Chemotherapy, targeted therapy, and immunotherapy are effective against most tumors, but
drug resistance remains a barrier to successful treatment. Lysine-specific demethylase 1 …

There have been substantial developments in the chemistry and biology of the acridone
alkaloids in the 16 years since the topic was last reviewed in this series of monographs …

The cytotoxic effects of a series of furanoacridones isolated from Ruta graveolens
L.(Rutaceae) and of two further acridone alkaloids (arborinine and evoxanthine) were …

Arborinine is a natural product isolated from G. parva leaf extracts, which displays potentially
antiproliferative activity against human cervical cancer cells. In contrast, its anticancer effects …

Alpha-fetoprotein (AFP), known largely as a growth-promoting agent, possesses a growth-
inhibitory motif recently identified as an occult epitopic segment in the third domain. The …

Two new cis-clerodane-type furanoditerpenes, crispenes F and G (1 and 2), together with
seven known compounds, were isolated from the stems of Tinospora crispa. Crispenes F …

BACKGROUND: Ruta graveolens is one of the most used phytomedicines. To date, there is
no report of determining the bioactivity of R. graveolens against cariogenic causing bacteria …

The aim of the present study was to investigate the anticancer properties of a set of
furanoacridone alkaloids, arborinine and evoxanthine, including the inhibitory effect of P …

Two previously undescribed indole alkaloids, 3-prenyl-5 (3-keto-but-1-enyl) indole and 3-
prenyl-indole-5-carbaldehyde, the structurally-related 3, 5-diprenyl indole and four known …

Pasteur and Joubert, in 1877, were among the first to recognize the potential of microbial
products as therapeutic agents and demonstrated that common microorganisms could …