Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

Most individuals adjust their caffeine intake according to the objective and subjective effects
induced by the methylxanthine. However, to reach the desired effects, the quantity of …

Caffeine is the most widely consumed psychoactive drug in the world. Natural sources of
caffeine include coffee, tea, and chocolate. Synthetic caffeine is also added to products to …

Many plants, including some of the commonly consumed herbs and spices in our daily food,
can be safely and effectively used to prevent and/or treat some health concerns. For …

The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

Most drugs of abuse easily cross the placenta and can affect fetal brain development. In
utero exposures to drugs thus can have long-lasting implications for brain structure and …

The consumption of caffeine (an adenosine receptor antagonist) correlates inversely with
depression and memory deterioration, and adenosine A2A receptor (A2AR) antagonists …

JCI - Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and
learning-dependent transcription Go to JCI Insight About Editors Consulting Editors For authors …

INTRODUCTION During development, brain circuits go through phases of synapse
formation, stabilization, or elimination. γ-aminobutyric acid–mediated (GABAergic) synapse …

The incidence of preterm birth is increasing, leading to a growing population with potential
long-term pulmonary complications. Apnoea of prematurity (AOP) is one of the major …