Hope on the Horizon: New and Future Therapies for sickle cell disease

FA Kuriri - Journal of Clinical Medicine, 2023 - mdpi.com
This article provides an overview of conventional, new, and future treatment options for
sickle cell disease (SCD), a genetic disorder affecting the production of hemoglobin. Current …

Mouse models of sickle cell disease: imperfect and yet very informative

S Kamimura, M Smith, S Vogel, LEF Almeida… - Blood Cells, Molecules …, 2024 - Elsevier
The root cause of sickle cell disease (SCD) has been known for nearly a century, however,
few therapies to treat the disease are available. Over several decades of work, with …

Endari treatment ameliorates sickle cell-related disruption in intestinal barrier functions and is associated with prolonged survival in sickle cell mice

E Haroun, SH Lim, D Dutta - Hematology, 2024 - Taylor & Francis
Background Endari (L-glutamine) is a conditional amino acid that reduces the frequency of
vaso-occlusive crisis (VOC) in sickle cell disease (SCD). Aim To investigate whether Endari …