The organization of cells into interconnected structures such as animal tissues requires a
sophisticated system directing receptors and adhesion proteins to the cell surface. The …

All cellular compartments are separated from the external environment by a membrane,
which consists of a lipid bilayer. Subcellular structures, including clathrin-coated pits …

The main organelles of the secretory and endocytic pathways—the endoplasmic reticulum
(ER) and endosomes, respectively—are connected through contact sites whose numbers …

The physical continuity of axons over long cellular distances poses challenges for their
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …

Adult mammalian central nervous system axons have intrinsically poor regenerative
capacity, so axonal injury has permanent consequences. One approach to enhancing …

Anionic lipids act as signals for the recruitment of proteins containing cationic clusters to
biological membranes. A family of anionic lipids known as the phosphoinositides (PIPs) are …

Peripheral membrane proteins (PMPs) can reversibly and specifically bind to biological
membranes to carry out functions such as cell signalling, enzymatic activity, or membrane …

Membrane proteins have diverse functions within cells and are well-established drug
targets. The advances in membrane protein structural biology have revealed drug and lipid …

Intracellular membrane trafficking, which is involved in diverse cellular processes, is
dynamic and difficult to study in a spatiotemporal manner. Here we report an optogenetic …

Lysosomes are the main degradative compartments of mammalian cells and serve as
platforms for cellular nutrient signaling and sterol transport. The diverse functions of …