Orchestration of cell surface proteins by Rab11
T Welz, J Wellbourne-Wood, E Kerkhoff - Trends in cell biology, 2014 - cell.com
The organization of cells into interconnected structures such as animal tissues requires a
sophisticated system directing receptors and adhesion proteins to the cell surface. The …
sophisticated system directing receptors and adhesion proteins to the cell surface. The …
Dynamic shaping of cellular membranes by phospholipids and membrane-deforming proteins
All cellular compartments are separated from the external environment by a membrane,
which consists of a lipid bilayer. Subcellular structures, including clathrin-coated pits …
which consists of a lipid bilayer. Subcellular structures, including clathrin-coated pits …
Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth
C Raiborg, EM Wenzel, NM Pedersen, H Olsvik… - Nature, 2015 - nature.com
The main organelles of the secretory and endocytic pathways—the endoplasmic reticulum
(ER) and endosomes, respectively—are connected through contact sites whose numbers …
(ER) and endosomes, respectively—are connected through contact sites whose numbers …
Axonal endoplasmic reticulum dynamics and its roles in neurodegeneration
The physical continuity of axons over long cellular distances poses challenges for their
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …
Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS
V Petrova, CS Pearson, J Ching, JR Tribble… - Nature …, 2020 - nature.com
Adult mammalian central nervous system axons have intrinsically poor regenerative
capacity, so axonal injury has permanent consequences. One approach to enhancing …
capacity, so axonal injury has permanent consequences. One approach to enhancing …
Cellular and molecular interactions of phosphoinositides and peripheral proteins
RV Stahelin, JL Scott, CT Frick - Chemistry and physics of lipids, 2014 - Elsevier
Anionic lipids act as signals for the recruitment of proteins containing cationic clusters to
biological membranes. A family of anionic lipids known as the phosphoinositides (PIPs) are …
biological membranes. A family of anionic lipids known as the phosphoinositides (PIPs) are …
Specific interactions of peripheral membrane proteins with lipids: what can molecular simulations show us?
AH Larsen, LH John, MSP Sansom… - Bioscience …, 2022 - portlandpress.com
Peripheral membrane proteins (PMPs) can reversibly and specifically bind to biological
membranes to carry out functions such as cell signalling, enzymatic activity, or membrane …
membranes to carry out functions such as cell signalling, enzymatic activity, or membrane …
Alchemical Free Energy Calculations on Membrane-Associated Proteins
Membrane proteins have diverse functions within cells and are well-established drug
targets. The advances in membrane protein structural biology have revealed drug and lipid …
targets. The advances in membrane protein structural biology have revealed drug and lipid …
Optogenetic oligomerization of Rab GTPases regulates intracellular membrane trafficking
Intracellular membrane trafficking, which is involved in diverse cellular processes, is
dynamic and difficult to study in a spatiotemporal manner. Here we report an optogenetic …
dynamic and difficult to study in a spatiotemporal manner. Here we report an optogenetic …
Phosphoinositides in the control of lysosome function and homeostasis
Lysosomes are the main degradative compartments of mammalian cells and serve as
platforms for cellular nutrient signaling and sterol transport. The diverse functions of …
platforms for cellular nutrient signaling and sterol transport. The diverse functions of …