Immunogenicity has imposed a challenge to efficacy and safety evaluation of adeno-
associated virus (AAV) vector-based gene therapies. Mild to severe adverse events …

Influenza vaccines remain the most effective tools to prevent flu and its complications.
Trivalent or quadrivalent inactivated influenza vaccines primarily elicit antibodies towards …

T-cell therapy after hematopoietic stem cell transplantation (HSCT) has been used alone or
in combination with immunosuppression to cure hematologic malignancies and to prevent …

The enzyme-linked immunosorbent spot (ELISpot) assay is one of the most commonly used
methods to measure antigen-specific T cells in both mice and humans. Some of the primary …

Cytomegalovirus (CMV) infection is still a major complication after kidney transplantation.
Although cytotoxic CMV-specific T cells play a crucial role controlling CMV survival and …

Cryopreserved peripheral blood mononuclear cells (PBMC) constitute an important
component of immune monitoring studies as they allow for efficient batch-testing of samples …

Assessment of donor-specific alloreactive memory/effector T cell responses using an IFN-γ
Elispot assay has been suggested to be a novel immune-monitoring tool for evaluating the …

Purpose: To facilitate development of innovative immunotherapy approaches, especially for
treatment concepts exploiting the potential benefits of personalized therapy, there is a need …

The T cell system plays an essential role in infections, allergic reactions, tumor and
transplant rejection, as well as autoimmune diseases. It does so by the selective …

The enzyme‐linked immunospot (ELISPOT) assay has advanced into a useful and widely
applicable tool for the evaluation of T‐cell responses in both humans and animal models of …