Chronic pain is a maladaptive condition affecting 7%-10% of the population worldwide and
can be accompanied by depression, anxiety, and insomnia. In particular, chronic pain is …

Chronic pain relief remains an unmet medical need. Current research points to a substantial
contribution of glia-neuron interaction in its pathogenesis. Particularly, microglia play a …

Chronic pain is challenging to treat due to the limited therapeutic options and adverse side-
effects of therapies. Astrocytes are the most abundant glial cells in the central nervous …

Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …

High endothelial venule protein/SPARC-like 1 (hevin/Sparcl1) is an astrocyte-secreted
protein that regulates synapse formation in the brain. Here we show that astrocytic hevin …

Studies over the past two decades have demonstrated that astrocytes are tightly associated
with neurons and play pivotal roles in neural circuit development, operation, and adaptation …

The sensory inflow from the periphery that triggers innocuous and painful sensations is
highly complex, capturing key elements of the nature of any stimulus, its location, intensity …

The transition from acute to chronic pain is an ongoing major problem for individuals, society
and healthcare systems around the world. It is clear chronic pain is a complex …

Reactive astrocytes are commonly activated in the spinal dorsal horn (SDH) of various
animal models of pathological pain. Previous investigations suggest an association between …

The high prevalence of pain and the at times low efficacy of current treatments represent a
significant challenge to healthcare systems worldwide. Effective treatment strategies require …