Several membrane transporters belonging to the adenosine triphosphate‐binding cassette
(ABC) and solute carrier (SLC) families can transport drugs and drug metabolites and …

Adenosine triphosphate-binding cassette (ABC) transporters, such as P-glycoprotein (Pgp,
ABCB1), breast cancer resistance protein (BCRP, ABCG2) and multidrug resistance …

Background Studies in rodent models of epilepsy suggest that multidrug efflux transporters
at the blood–brain barrier, such as P-glycoprotein, might contribute to pharmacoresistance …

The multiple-drug resistance (MDR) transporter P-glycoprotein (P-gp) is highly expressed at
the human blood–brain barrier (BBB). P-gp actively effluxes a wide variety of drugs from the …

Using positron emission tomography (PET) imaging we assessed, in vivo, the interaction
between a microdose of (R)‐[11C] verapamil (a P‐glycoprotein (Pgp) substrate) and …

Purpose Overactivity of the multidrug efflux transporter P-glycoprotein (P-gp) at the blood-
brain barrier (BBB) is believed to play an important role in resistance to central nervous …

The multidrug efflux transporter P-glycoprotein (P-gp) is expressed in high concentrations at
the blood–brain barrier (BBB) and is believed to be implicated in resistance to central …

Tariquidar, a potent, nontoxic, third-generation P-glycoprotein (P-gp) inhibitor, is a possible
reversal agent for central nervous system drug resistance. In animal studies, tariquidar has …

The effects of metoclopramide on the central nervous system (CNS) in patients suggest
substantial brain distribution. Previous data suggest that metoclopramide brain kinetics may …

We report on the use of the voltage-gated calcium channel blocker (Vg-CCB), verapamil, as
an add-on anticonvulsant medication in two girls, 4 and 14 years of age, who were affected …