Mitochondrial dysfunction and oxidative stress in heart disease

JN Peoples, A Saraf, N Ghazal, TT Pham… - … & molecular medicine, 2019 - nature.com
Beyond their role as a cellular powerhouse, mitochondria are emerging as integral players
in molecular signaling and cell fate determination through reactive oxygen species (ROS) …

Mitochondrial dysfunction in pathophysiology of heart failure

B Zhou, R Tian - The Journal of clinical investigation, 2018 - Am Soc Clin Investig
Mitochondrial dysfunction has been implicated in the development of heart failure. Oxidative
metabolism in mitochondria is the main energy source of the heart, and the inability to …

Gut microbiota protects honey bees (Apis mellifera L.) against polystyrene microplastics exposure risks

K Wang, J Li, L Zhao, X Mu, C Wang, M Wang… - Journal of Hazardous …, 2021 - Elsevier
Microplastic contamination is not only a pressing environmental concern in oceans, but also
terrestrial ecosystems. However, little is known about its potential impacts on pollinators …

[HTML][HTML] The role of reactive oxygen species in the pathophysiology of cardiovascular diseases and the clinical significance of myocardial redox

D Moris, M Spartalis, E Spartalis… - Annals of …, 2017 - ncbi.nlm.nih.gov
Acute and chronic excessive intracellular increase of reactive oxygen species (ROS) is
involved in the development and progression of cardiovascular diseases. ROS are by …

PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function

F Billia, L Hauck, F Konecny, V Rao… - Proceedings of the …, 2011 - National Acad Sciences
Oxidative stress is caused by an imbalance between reactive oxygen species (ROS)
production and the ability of an organism to eliminate these toxic intermediates. Mutations in …

Lipid peroxidation in atherosclerotic cardiovascular diseases

E Gianazza, M Brioschi… - Antioxidants & redox …, 2021 - liebertpub.com
Significance: Atherosclerotic cardiovascular diseases (ACVDs) continue to be a primary
cause of mortality worldwide in adults aged 35–70 years, occurring more often in countries …

Selenium, selenoproteins, and heart failure: current knowledge and future perspective

AA Al-Mubarak, P van der Meer, N Bomer - Current heart failure reports, 2021 - Springer
Abstract Purpose of Review (Mal-) nutrition of micronutrients, like selenium, has great impact
on the human heart and improper micronutrient intake was observed in 30–50% of patients …

Daily rhythms of phytomelatonin signaling modulate diurnal stomatal closure via regulating reactive oxygen species dynamics in Arabidopsis

D Li, J Wei, Z Peng, W Ma, Q Yang… - Journal of Pineal …, 2020 - Wiley Online Library
Melatonin is a well‐studied neurohormone oscillating in a 24‐h cycle in vertebrates.
Phytomelatonin is widespread in plant kingdom, but it remains elusive whether this newly …

The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling

YX Ji, P Zhang, XJ Zhang, YC Zhao, KQ Deng… - Nature …, 2016 - nature.com
Tumour necrosis factor receptor-associated factor 6 (TRAF6) is a ubiquitin E3 ligase that
regulates important biological processes. However, the role of TRAF6 in cardiac hypertrophy …

NADPH oxidases in heart failure: poachers or gamekeepers?

M Zhang, A Perino, A Ghigo, E Hirsch… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: Oxidative stress is involved in the pathogenesis of heart failure but clinical
antioxidant trials have been unsuccessful. This may be because effects of reactive oxygen …