Current status and applications of genome-scale metabolic models

C Gu, GB Kim, WJ Kim, HU Kim, SY Lee - Genome biology, 2019 - Springer
Genome-scale metabolic models (GEMs) computationally describe gene-protein-reaction
associations for entire metabolic genes in an organism, and can be simulated to predict …

Bioengineering of microalgae: recent advances, perspectives, and regulatory challenges for industrial application

G Kumar, A Shekh, S Jakhu, Y Sharma… - … in Bioengineering and …, 2020 - frontiersin.org
Microalgae, due to their complex metabolic capacity, are being continuously explored for
nutraceuticals, pharmaceuticals, and other industrially important bioactives. However …

The impact of synthetic biology for future agriculture and nutrition

MS Roell, MD Zurbriggen - Current Opinion in Biotechnology, 2020 - Elsevier
Highlights•Synthetic metabolic pathways to improve plant carbon efficiency.•Reducing
synthetic fertilizer usage in agriculture by optimizing plant nitrogen and phosphorous …

A critical perspective on the scope of interdisciplinary approaches used in fourth-generation biofuel production

V Godbole, MK Pal, P Gautam - Algal Research, 2021 - Elsevier
The use of algae in biofuel production is more sustainable as compared to crop-based
resources as it doesn't compromise food security, rainforests, or arable land. Furthermore …

[HTML][HTML] Current status and applications of adaptive laboratory evolution in industrial microorganisms

SR Lee, P Kim - Journal of Microbiology and Biotechnology, 2020 - ncbi.nlm.nih.gov
Adaptive laboratory evolution (ALE) is an evolutionary engineering approach in artificial
conditions that improves organisms through the imitation of natural evolution. Due to the …

Towards model-driven characterization and manipulation of plant lipid metabolism

SM Correa, AR Fernie, Z Nikoloski, Y Brotman - Progress in lipid research, 2020 - Elsevier
Plant lipids have versatile applications and provide essential fatty acids in human diet.
Therefore, there has been a growing interest to better characterize the genetic basis …

Advances in engineering algae for biofuel production

AM Ruffing, RW Davis, TW Lane - Current opinion in biotechnology, 2022 - Elsevier
Highlights•High-throughput strain engineering increases algal biomass production and lipid
content.•Genome-scale models with omics data advance rational algal strain engineering.• …

Unveiling the potential of systems biology in biotechnology and biomedical research

S Saranya, L Thamanna, P Chellapandi - Systems Microbiology and …, 2024 - Springer
Abstract “In silico organisms” are computational genome-scale metabolic models used in
systems and synthetic biology developed by constraint-based metabolic simulations using …

Repositioning microbial biotechnology against COVID‐19: the case of microbial production of flavonoids

T Goris, Á Pérez‐Valero, I Martínez, D Yi… - Microbial …, 2021 - Wiley Online Library
Summary Coronavirus‐related disease 2019 (COVID‐19) became a pandemic in February
2020, and worldwide researchers try to tackle the disease with approved drugs of all kinds …

[HTML][HTML] Systems biology's role in leveraging microalgal biomass potential: Current status and future perspectives

E Cunha, V Sousa, P Geada, JA Teixeira, AA Vicente… - Algal Research, 2023 - Elsevier
Microalgae are an eco-friendly and alternative source of several compounds that can be
applied in numerous biotechnological branches such as cosmetics, food, or pharmaceutical …