Abstract Rationale Serotonin (5-HT) neurotransmission is intimately linked to anxiety and
depression and a diverse body of evidence supports the involvement of the main inhibitory …

This systematic review summarizes pharmacogenetic studies on antidepressant response
and side effects. Out of the 17 genes we reviewed, 8 genes were entered into the meta …

Inhibition of serotonergic raphe neurons is mediated by somatodendritic 5-HT1A
autoreceptors, which may be increased in depressed patients. We report an association of …

The genetic basis of major depressive disorder (MDD) has been investigated extensively,
but the identification of MDD genes has been hampered by conflicting results from …

The serotonin system is implicated in major depression and suicide and is negatively
regulated by somatodendritic 5-HT1A autoreceptors. Desensitization of 5-HT1A …

Objective: Although it is well established that depressive symptoms are associated with
recurrent cardiac events among cardiac patients and novel cardiac events among …

Antidepressants, such as serotonin or noradrenaline reuptake inhibitors (eg fluoxetine,
nefadozone) or 5-HT1A agonists (flibanserin), desensitize the 5-HT1A autoreceptor, which …

The serotonin-1A (5-HT1A) receptor serves as a hub to regulate the activity and actions of
the serotonin system, and is expressed both as a presynaptic autoreceptor on raphe …

Dysfunction of the serotonin (5-HT1A) receptor (5-HTR1A) has been implicated in mood
disorders, anxiety disorders, psychosis and the action of antidepressants. A common C …

The serotonin 1A receptor gene (HTR1A) has been associated with mood disorders (MDs),
including major depressive disorder (MDD) and bipolar disorder (BP). Therefore, we …