Phototherapy and optical waveguides for the treatment of infection

D Wang, ML Kuzma, X Tan, TC He, C Dong… - Advanced drug delivery …, 2021 - Elsevier
With rapid emergence of multi-drug resistant microbes, it is imperative to seek alternative
means for infection control. Optical waveguides are an auspicious delivery method for …

Drug repurposing against SARS-CoV-1, SARS-CoV-2 and MERS-CoV

S Aherfi, B Pradines, C Devaux, S Honore… - Future …, 2021 - Taylor & Francis
Since the beginning of the COVID-19 pandemic, large in silico screening studies and
numerous in vitro studies have assessed the antiviral activity of various drugs on SARS-CoV …

Small-molecule inhibitors of the coronavirus spike: ACE2 protein–protein interaction as blockers of viral attachment and entry for SARS-CoV-2

D Bojadzic, O Alcazar, J Chen, ST Chuang… - ACS infectious …, 2021 - ACS Publications
Inhibitors of the protein–protein interaction (PPI) between the SARS-CoV-2 spike protein
and human ACE2 (hACE2), which acts as a ligand–receptor pair that initiates the viral …

Methylene blue inhibits the SARS-CoV-2 spike–ACE2 protein-protein interaction–a mechanism that can contribute to its antiviral activity against COVID-19

D Bojadzic, O Alcazar, P Buchwald - Frontiers in pharmacology, 2021 - frontiersin.org
Due to our interest in the chemical space of organic dyes to identify potential small-molecule
inhibitors (SMIs) for protein-protein interactions (PPIs), we initiated a screen of such …

Visible light–driven advanced oxidation processes to remove emerging contaminants from water and wastewater: a review

P Zawadzki - Water, Air, & Soil Pollution, 2022 - Springer
The scientific data review shows that advanced oxidation processes based on the hydroxyl
or sulfate radicals are of great interest among the currently conventional water and …

Of mitochondrion and COVID-19

KO Alfarouk, STS Alhoufie, A Hifny… - Journal of enzyme …, 2021 - Taylor & Francis
COVID-19, a pandemic disease caused by a viral infection, is associated with a high
mortality rate. Most of the signs and symptoms, eg cytokine storm, electrolytes imbalances …

Non-oncologic applications of nanomedicine-based photo-therapy

SW Yoo, G Oh, JC Ahn, E Chung - Biomedicines, 2021 - mdpi.com
Phototherapy is widely applied to various human diseases. Nanomedicine-based
phototherapy can be classified into photodynamic therapy (PDT) and photothermal therapy …

Methylene Blue has a potent antiviral activity against SARS-CoV-2 and H1N1 influenza virus in the absence of UV-activation in vitro

V Cagno, C Medaglia, A Cerny, T Cerny… - Scientific Reports, 2021 - nature.com
Methylene blue is an FDA (Food and Drug Administration) and EMA (European Medicines
Agency) approved drug with an excellent safety profile. It displays broad-spectrum virucidal …

Photodynamic disinfection of SARS-CoV-2 clinical samples using a methylene blue formulation

CS Lobo, P Rodrigues-Santos, D Pereira… - Photochemical & …, 2022 - Springer
The amplitude of the coronavirus disease 2019 (COVID-19) pandemic motivated global
efforts to find therapeutics that avert severe forms of this illness. The urgency of the medical …

Structures of the SARS-CoV-2 spike glycoprotein and applications for novel drug development

XH Liu, T Cheng, BY Liu, J Chi, T Shu… - Frontiers in …, 2022 - frontiersin.org
COVID-19 caused by SARS-CoV-2 has raised a health crisis worldwide. The high morbidity
and mortality associated with COVID-19 and the lack of effective drugs or vaccines for SARS …