The reaction potential energy surface (PES), and thus the mechanism of bimolecular
nucleophilic substitution (SN2), depends profoundly on the nature of the nucleophile and …

HNO (nitroxyl, azanone), joined the 'biologically relevant reactive nitrogen species' family in
the 2000s. Azanone is impossible to store due to its high reactivity and inherent low stability …

Understanding the complex interplay among gasotransmitters is of great significance but
remains technically challenging. In this study, we present the design and synthesis of a …

Azanone (HNO) is a reactive nitrogen species with pronounced biological activity and high
therapeutic potential for cardiovascular dysfunction. A critical barrier to understanding the …

A therapeutic strategy that could address colitis of multiple etiologies while restoring the
dysbiosis of gut microbiota is attractive. Here, Aurozyme, a novel nanomedicine comprised …

In vivo levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are
critical to many physiological and pathological processes. Because of the distinct differences …

Interactions between small inorganic molecules are fundamental to the understanding of
basic reaction mechanisms and some of the initial processes of chemical evolution that …

The redox chemistry of H2S with NO and other oxidants containing the NO group is
discussed on a mechanistic basis because of the expanding interest in their biological …

Detection of nitroxyl (HNO), the transient one-electron reduced form of nitric oxide, is a
significant challenge owing to its high reactivity with biological thiols (with rate constants as …

Nitroxyl, HNO/NO–, the one-electron reduced form of NO, is suggested to take part in distinct
signaling pathways in mammals and is also a key intermediate in various heme-catalyzed …