Anti‐inflammatory therapies in myocardial infarction: failures, hopes and challenges

S Huang, NG Frangogiannis - British journal of pharmacology, 2018 - Wiley Online Library
In the infarcted heart, the damage‐associated molecular pattern proteins released by
necrotic cells trigger both myocardial and systemic inflammatory responses. Induction of …

Inflammation as a therapeutic target in myocardial infarction: learning from past failures to meet future challenges

A Saxena, I Russo, NG Frangogiannis - Translational Research, 2016 - Elsevier
In the infarcted myocardium, necrotic cardiomyocytes release danger signals, activating an
intense inflammatory response. Inflammatory pathways play a crucial role in regulation of a …

Use of a supramolecular polymeric hydrogel as an effective post-operative pericardial adhesion barrier

LM Stapleton, AN Steele, H Wang… - Nature biomedical …, 2019 - nature.com
Post-operative adhesions form as a result of normal wound healing processes following any
type of surgery. In cardiac surgery, pericardial adhesions are particularly problematic during …

[HTML][HTML] A unique collateral artery development program promotes neonatal heart regeneration

S Das, AB Goldstone, H Wang, J Farry, G D'Amato… - Cell, 2019 - cell.com
Collateral arteries are an uncommon vessel subtype that can provide alternate blood flow to
preserve tissue following vascular occlusion. Some patients with heart disease develop …

Injectable decellularized extracellular matrix hydrogel containing stromal cell-derived factor 1 promotes transplanted cardiomyocyte engraftment and functional …

K Wu, Y Wang, H Yang, Y Chen, K Lu… - … Applied Materials & …, 2023 - ACS Publications
Transplantation of exogenous cardiomyocytes (CMs) is a hopeful method to treat myocardial
infarction (MI). However, its clinical application still remains challenging due to low retention …

Vascularization of three-dimensional engineered tissues for regenerative medicine applications

JJ Kim, L Hou, NF Huang - Acta biomaterialia, 2016 - Elsevier
Engineering of three-dimensional (3D) tissues is a promising approach for restoring
diseased or dysfunctional myocardium with a functional replacement. However, a major …

Chemokines in myocardial infarction

B Chen, NG Frangogiannis - Journal of cardiovascular translational …, 2021 - Springer
In the infarcted myocardium, cardiomyocyte necrosis triggers an intense inflammatory
reaction that not only is critical for cardiac repair, but also contributes to adverse remodeling …

An innovative biologic system for photon-powered myocardium in the ischemic heart

JE Cohen, AB Goldstone, MJ Paulsen, Y Shudo… - Science …, 2017 - science.org
Coronary artery disease is one of the most common causes of death and disability, afflicting
more than 15 million Americans. Although pharmacological advances and revascularization …

State-of-the-art methods for evaluation of angiogenesis and tissue vascularization: a scientific statement from the American Heart Association

M Simons, K Alitalo, BH Annex, HG Augustin… - Circulation …, 2015 - Am Heart Assoc
The American Heart Association makes every effort to avoid any actual or potential conflicts
of interest that may arise as a result of an outside relationship or a personal, professional, or …

3D and 4D bioprinting of the myocardium: current approaches, challenges, and future prospects

CS Ong, L Nam, K Ong, A Krishnan… - BioMed research …, 2018 - Wiley Online Library
3D and 4D bioprinting of the heart are exciting notions in the modern era. However,
myocardial bioprinting has proven to be challenging. This review outlines the methods …