Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

Calcium signaling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is
bound to buffers, with typically only∼ 1% being freely ionized at resting levels in most cells …

We develop a point model of the cardiac myofilament (MF) to simulate a wide variety of
experimental muscle characterizations including Force-Ca relations and twitches under …

Protein complexes are highly dynamic entities that display substantial diversity in their
assembly, post-translational modifications, and non-covalent interactions, allowing them to …

Various human diseases can disrupt the balance between muscle contraction and
relaxation. Sarcomeric modulators can be used to readjust this balance either indirectly by …

Dilated cardiomyopathy and hypertrophic cardiomyopathy (HCM) can be caused by
mutations in thin filament regulatory proteins of the contractile apparatus. In vitro functional …

In striated muscle, the protein troponin complex turns contraction on and off in a calcium-
dependent manner. The calcium-sensing component of the complex is troponin C, which is …

We focus here on the modulation of thin filament activity by cardiac troponin I
phosphorylation as an integral and adaptive mechanism in cardiac homeostasis and as a …

BACKGROUND: Modulating myosin function is a novel therapeutic approach in patients with
cardiomyopathy. Danicamtiv is a novel myosin activator with promising preclinical data that …

In skeletal muscle fibers, action potentials elicit contractions by releasing calcium ions
(Ca2+) from the sarcoplasmic reticulum. Experiments on individual mouse muscle fibers …