The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from
over-exuberant responses to pathogens and microbiota, while playing important roles in …

Mitochondria have a central role in regulating a range of cellular activities and host
responses upon bacterial infection. Multiple pathogens affect mitochondria dynamics and …

Immune checkpoint blockade (ICB) therapy has attracted widespread attention in cancer
treatment. Due to the low immunogenicity and immune suppression state in the tumor …

The protective effects of the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on
unrelated infections are thought to be mediated by long-term metabolic changes and …

To understand how infection by Mycobacterium tuberculosis (Mtb) is modulated by host cell
phenotype, we characterized those host phagocytes that controlled or supported bacterial …

Background Heterologous effects of vaccines are mediated by “trained immunity,” whereby
myeloid cells are metabolically and epigenetically reprogrammed, resulting in heightened …

Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

Abstract Changes in cellular metabolism are associated with the activation of diverse
immune subsets. These changes are fuelled by nutrients including glucose, amino acids …

Viruses and intracellular bacterial pathogens (IBPs) have in common the need of suitable
host cells for efficient replication and proliferation during infection. In human infections, the …

HIF is a transcription factor that plays an essential role in the cellular response to low
oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In …