mRNA-based cancer therapeutics

C Liu, Q Shi, X Huang, S Koo, N Kong, W Tao - Nature Reviews Cancer, 2023 - nature.com
Due to the fact that mRNA technology allows the production of diverse vaccines and
treatments in a shorter time frame and with reduced expense compared to conventional …

Nanotechnology-based mRNA vaccines

S Chen, X Huang, Y Xue, E Álvarez-Benedicto… - Nature Reviews …, 2023 - nature.com
Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and
precise immune responses against infectious diseases and cancers. Compared with …

Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy

Y Zong, Y Lin, T Wei, Q Cheng - Advanced Materials, 2023 - Wiley Online Library
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …

[HTML][HTML] Smartphone-based platforms implementing microfluidic detection with image-based artificial intelligence

B Wang, Y Li, M Zhou, Y Han, M Zhang, Z Gao… - Nature …, 2023 - nature.com
The frequent outbreak of global infectious diseases has prompted the development of rapid
and effective diagnostic tools for the early screening of potential patients in point-of-care …

mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy

F Li, XQ Zhang, W Ho, M Tang, Z Li, L Bu… - Nature communications, 2023 - nature.com
Synergistically improving T-cell responsiveness is promising for favorable therapeutic
outcomes in immunologically cold tumors, yet current treatments often fail to induce a …

Advances of medical nanorobots for future cancer treatments

X Kong, P Gao, J Wang, Y Fang, KC Hwang - Journal of Hematology & …, 2023 - Springer
Early detection and diagnosis of many cancers is very challenging. Late stage detection of a
cancer always leads to high mortality rates. It is imperative to develop novel and more …

Materials engineering strategies for cancer vaccine adjuvant development

X Zhang, B Yang, Q Ni, X Chen - Chemical Society Reviews, 2023 - pubs.rsc.org
Cancer vaccines have emerged as a powerful new tool for cancer immunotherapy.
Adjuvants are vaccine ingredients that enhance the strength, velocity, and duration of the …

The use of RNA-based treatments in the field of cancer immunotherapy

M Chehelgerdi, M Chehelgerdi - Molecular Cancer, 2023 - Springer
Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …

Stimuli-responsive gene delivery nanocarriers for cancer therapy

Q Zhang, G Kuang, W Li, J Wang, H Ren, Y Zhao - Nano-Micro Letters, 2023 - Springer
Gene therapy provides a promising approach in treating cancers with high efficacy and
selectivity and few adverse effects. Currently, the development of functional vectors with …

[HTML][HTML] Engineering nanoparticle toolkits for mRNA delivery

B Sun, W Wu, EA Narasipura, Y Ma, C Yu… - Advanced Drug Delivery …, 2023 - Elsevier
The concept of using mRNA to produce its own medicine in situ in the body makes it an ideal
drug candidate, holding great potential to revolutionize the way we approach medicine. The …