Extensive studies on nanomedicines have been conducted for drug delivery and disease
diagnosis (especially for cancer therapy). However, the intracellular and in vivo biofate of …

Bioavailability is an eternal topic that cannot be circumvented by peroral drug delivery.
Adequate blood drug exposure after oral administration is a prerequisite for effective …

Diabetes is a chronic metabolic disease characterized by lack of insulin in the body leading
to failure of blood glucose regulation. Diabetes patients usually need frequent insulin …

For drug nanocrystals (NCs), particle shapes can affect aqueous solubility, dissolution rate
and oral bioavailability. However, the effects of particle shapes on the transport of NCs …

To maximize therapeutic effects and minimize unwanted effects, the interest in drug targeting
to the endoplasmic reticulum (ER) or Golgi apparatus (GA) has been recently growing …

The elucidation of the oral absorption of natural polysaccharides contributes to their further
research and utilization. Herein, to explore the absorption of a pectin-type polysaccharide …

Oral chemotherapy can improve the life quality of patients; however, the therapeutic effects
are limited by low bioavailability and rapid in vivo elimination of anticancer drugs. Here, we …

Nanomaterials are now being used in a wide variety of biomedical applications. Medical and
health-related issues, however, have raised major concerns, in view of the potential risks of …

Background Effective oral delivery of drugs remains a major challenge given their possible
undesirable physicochemical properties, physicochemical factors, and the physiological …

Background Mesenteric lymph nodes (MLNs) are critical draining lymph nodes of the
immune system that accommodate more than half of the body's lymphocytes, suggesting …