Abstract Topoisomerase IB (Top1), a subcategory of DNA topoisomerase enzymes is
expressed much higher in several tumor cells. Therefore, modulating the activity of Top1 in …

In recent years, palladium‐catalyzed direct C2 or C5 arylation of heteroaromatic compounds
with aryl halides by C H bond activation has become a popular method for generating …

The nitro group is considered to be a versatile and unique functional group in medicinal
chemistry. Despite a long history of use in therapeutics, the nitro group has toxicity issues …

The significant role of topoisomerases in the control of DNA chain topology has been
confirmed in numerous research conducted worldwide. The prevalence of these enzymes …

DNA topoisomerases constitute a large family of enzymes that are essential for all domains
of life. Although they share general reaction chemistry and the capacity to govern DNA …

Multidrug resistance (MDR) is a major obstacle to the effective treatment of cancer. Cellular
overproduction of P‐glycoprotein (P‐gp), which acts as an efflux pump for various anticancer …

The objectives of this study were to evaluate:(i) the influences of hydrogel geometry, DNA
molecular weight, and DNA conformation on DNA release from a silk-elastinlike protein …

Topoisomerase I (TopoI), an essential enzyme, produces a DNA single strand break
allowing DNA relaxation for replication. The enzymatic mechanism involves sequential …

Introduction: Topoisomerases (topos) are nuclear enzymes that resolve topological
problems associated with DNA during various genetic processes. The essential role of topos …

5 H-8, 9-Dimethoxy-5-(2-N, N-dimethylaminoethyl)-2, 3-methylenedioxydibenzo [c, h][1, 6]
naphthyridin-6-one (ARC-111) has potent TOP1-targeting activity and pronounced antitumor …