Salmonella Typhimurium and inflammation: a pathogen-centric affair
JE Galán - Nature Reviews Microbiology, 2021 - nature.com
Microbial infections are controlled by host inflammatory responses that are initiated by
innate immune receptors after recognition of conserved microbial products. As inflammation …
innate immune receptors after recognition of conserved microbial products. As inflammation …
Macropinocytosis in different cell types: similarities and differences
XP Lin, JD Mintern, PA Gleeson - Membranes, 2020 - mdpi.com
Macropinocytosis is a unique pathway of endocytosis characterised by the nonspecific
internalisation of large amounts of extracellular fluid, solutes and membrane in large …
internalisation of large amounts of extracellular fluid, solutes and membrane in large …
Macropinocytosis: new insights into its underappreciated role in innate immune cell surveillance
J Canton - Frontiers in immunology, 2018 - frontiersin.org
Macropinocytosis has received increasing attention in recent years for its various roles in
nutrient acquisition, immune surveillance, and virus and cancer pathologies. In most cases …
nutrient acquisition, immune surveillance, and virus and cancer pathologies. In most cases …
The role of PI3Kγ in the immune system: new insights and translational implications
Over the past two decades, new insights have positioned phosphoinositide 3-kinase-γ
(PI3Kγ) as a context-dependent modulator of immunity and inflammation. Recent advances …
(PI3Kγ) as a context-dependent modulator of immunity and inflammation. Recent advances …
[HTML][HTML] Macropinosome formation by tent pole ruffling in macrophages
ND Condon, JM Heddleston, TL Chew… - The Journal of cell …, 2018 - ncbi.nlm.nih.gov
Pathogen-mediated activation of macrophages arms innate immune responses that include
enhanced surface ruffling and macropinocytosis for environmental sampling and receptor …
enhanced surface ruffling and macropinocytosis for environmental sampling and receptor …
Signalling, sorting and scaffolding adaptors for Toll-like receptors
Toll-like receptors (TLRs) are danger-sensing receptors that typically propagate self-limiting
inflammatory responses, but can unleash uncontrolled inflammation in non-homeostatic or …
inflammatory responses, but can unleash uncontrolled inflammation in non-homeostatic or …
Macropinocytosis, mTORC1 and cellular growth control
The growth and proliferation of metazoan cells are driven by cellular nutrient status and by
extracellular growth factors. Growth factor receptors on cell surfaces initiate biochemical …
extracellular growth factors. Growth factor receptors on cell surfaces initiate biochemical …
TLR crosstalk activates LRP1 to recruit Rab8a and PI3Kγ for suppression of inflammatory responses
The multi-ligand endocytic receptor, low-density lipoprotein-receptor-related protein 1
(LRP1), has anti-inflammatory roles in disease. Here, we reveal that pathogen-activated Toll …
(LRP1), has anti-inflammatory roles in disease. Here, we reveal that pathogen-activated Toll …
Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology
AJ Takeda, TJ Maher, Y Zhang, SM Lanahan… - Nature …, 2019 - nature.com
Abstract Phosphatidylinositol 3-kinase-gamma (PI3Kγ) is highly expressed in leukocytes
and is an attractive drug target for immune modulation. Different experimental systems have …
and is an attractive drug target for immune modulation. Different experimental systems have …
Constitutive and stimulated macropinocytosis in macrophages: roles in immunity and in the pathogenesis of atherosclerosis
SA Doodnauth, S Grinstein… - … Transactions of the …, 2019 - royalsocietypublishing.org
Macrophages respond to several stimuli by forming florid membrane ruffles that lead to fluid
uptake by macropinocytosis. This type of induced macropinocytosis, executed by a variety of …
uptake by macropinocytosis. This type of induced macropinocytosis, executed by a variety of …