Microbial infections are controlled by host inflammatory responses that are initiated by
innate immune receptors after recognition of conserved microbial products. As inflammation …

Macropinocytosis is a unique pathway of endocytosis characterised by the nonspecific
internalisation of large amounts of extracellular fluid, solutes and membrane in large …

Macropinocytosis has received increasing attention in recent years for its various roles in
nutrient acquisition, immune surveillance, and virus and cancer pathologies. In most cases …

Over the past two decades, new insights have positioned phosphoinositide 3-kinase-γ
(PI3Kγ) as a context-dependent modulator of immunity and inflammation. Recent advances …

Pathogen-mediated activation of macrophages arms innate immune responses that include
enhanced surface ruffling and macropinocytosis for environmental sampling and receptor …

Toll-like receptors (TLRs) are danger-sensing receptors that typically propagate self-limiting
inflammatory responses, but can unleash uncontrolled inflammation in non-homeostatic or …

The growth and proliferation of metazoan cells are driven by cellular nutrient status and by
extracellular growth factors. Growth factor receptors on cell surfaces initiate biochemical …

The multi-ligand endocytic receptor, low-density lipoprotein-receptor-related protein 1
(LRP1), has anti-inflammatory roles in disease. Here, we reveal that pathogen-activated Toll …

Abstract Phosphatidylinositol 3-kinase-gamma (PI3Kγ) is highly expressed in leukocytes
and is an attractive drug target for immune modulation. Different experimental systems have …

Macrophages respond to several stimuli by forming florid membrane ruffles that lead to fluid
uptake by macropinocytosis. This type of induced macropinocytosis, executed by a variety of …