Enveloped viruses encompass some of the most common human pathogens causing
infections of different severity, ranging from no or very few symptoms to lethal disease as …

Following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency
and periodically reactivates without causing symptoms in healthy individuals. In the absence …

Protein folding is a complex, error-prone process that often results in an irreparable protein
by-product. These by-products can be recognized by cellular quality control machineries …

Presumably because of the selective pressure exerted by the immune system, many viruses
have evolved proteins that interfere with antigen presentation by major histocompatibility …

▪ Abstract Classical class I molecules assemble in the endoplasmic reticulum (ER) with
peptides mostly generated from cytosolic proteins by the proteasome. The activity of the …

Human cytomegalovirus (HCMV), a betaherpesvirus, represents the major infectious cause
of birth defects, as well as an important pathogen for immunocompromised individuals. The …

The human cytomegalovirus UL18 gene product is a homolog of cellular major
histocompatibility (MHC) class I antigens. UL18 has been proposed to protect virus-infected …

This review describes the diverse array of pathways and molecular targets that are used by
viruses to elude immune detection and destruction. These include targeting of pathways for …

Human cytomegalovirus (HCMV) infection induces both innate immune responses including
Natural Killer cells as well as adaptive humoral and cell mediated (CD4+ helper, CD8+ …

The MHC-I antigen presentation (AP) pathway is key to shaping mammalian CD8+ T cell
immunity, with its aberrant expression closely linked to low tumor immunogenicity and …