A review of sorting, separation and isolation of cells and microbeads for biomedical applications: microfluidic approaches

A Dalili, E Samiei, M Hoorfar - Analyst, 2019 - pubs.rsc.org
Several biomedical analyses are performed on particular types of cells present in body
samples or using functionalized microparticles. Success in such analyses depends on the …

A holistic review of the state‐of‐the‐art microfluidics for exosome separation: an overview of the current status, existing obstacles, and future outlook

L Ding, X Yang, Z Gao, CY Effah, X Zhang, Y Wu, L Qu - Small, 2021 - Wiley Online Library
Exosomes, a class of small extracellular vesicles (30–150 nm), are secreted by almost all
types of cells into virtually all body fluids. These small vesicles are attracting increasing …

Dielectrophoresis for bioparticle manipulation

C Qian, H Huang, L Chen, X Li, Z Ge, T Chen… - International journal of …, 2014 - mdpi.com
As an ideal method to manipulate biological particles, the dielectrophoresis (DEP) technique
has been widely used in clinical diagnosis, disease treatment, drug development …

Recent advances in microfluidic technology for manipulation and analysis of biological cells (2007–2017)

MK Alam, E Koomson, H Zou, C Yi, CW Li, T Xu… - Analytica chimica …, 2018 - Elsevier
The pivotal role of microfluidic technology in life science and biomedical research is now
widely recognized. Indeed, microfluidics as a research tool is unparalleled in terms of its …

Integrated microfluidic platforms for tumor-derived exosome analysis

H Xu, BC Ye - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Exosomes are membrane-surrounded phospholipid nanovesicles secreted by most types of
cells and circulate in body fluids. Tumor-derived exosome packaged with abundantly tumor …

A planar dielectrophoresis-based chip for high-throughput cell pairing

CH Wu, RF Chen, Y Liu, ZM Yu, YW Jiang, X Cheng - Lab on a Chip, 2017 - pubs.rsc.org
This paper reports the design and fabrication of a planar chip for high-throughput cell
trapping and pairing (more than 2400 single cell–cell pairs in a microwell array) in a 1× 1.5 …

Rapid and efficient isolation and detection of extracellular vesicles from plasma for lung cancer diagnosis

J Chen, Y Xu, X Wang, D Liu, F Yang, X Zhu, Y Lu… - Lab on a Chip, 2019 - pubs.rsc.org
Extracellular vesicles (EVs) are cell-derived nanoscale vesicles that provide promising
biomarkers for the non-invasive diagnosis of cancer because they carry important cancer …

Microfluidics cell sample preparation for analysis: advances in efficient cell enrichment and precise single cell capture

L Huang, S Bian, Y Cheng, G Shi, P Liu, X Ye… - …, 2017 - pubs.aip.org
Single cell analysis has received increasing attention recently in both academia and clinics,
and there is an urgent need for effective upstream cell sample preparation. Two extremely …

Electric and electrochemical microfluidic devices for cell analysis

K Hiramoto, K Ino, Y Nashimoto, K Ito, H Shiku - Frontiers in chemistry, 2019 - frontiersin.org
Microfluidic devices are widely used for cell analysis, including applications for single-cell
analysis, healthcare, environmental monitoring, and organs-on-a-chip that mimic organs in …

Separation and sorting of cells in microsystems using physical principles

GH Lee, SH Kim, K Ahn, SH Lee… - … of Micromechanics and …, 2015 - iopscience.iop.org
In the last decade, microfabrication techniques have been combined with microfluidics and
applied to cell biology. Utilizing such new techniques, various cell studies have been …