Role of macrophages in acute lung injury and chronic fibrosis induced by pulmonary toxicants

DL Laskin, R Malaviya, JD Laskin - Toxicological Sciences, 2019 - academic.oup.com
A diverse group of toxicants has been identified that cause injury to the lung including gases
(eg, ozone, chlorine), particulates/aerosols (eg, diesel exhaust, fly ash, other combustion …

[HTML][HTML] Probiotics interact with lipids metabolism and affect gut health

T Wu, G Wang, Z Xiong, Y Xia, X Song, H Zhang… - Frontiers in …, 2022 - frontiersin.org
Probiotics have attracted much attention due to their ability to modulate host intestinal
microbe, participate in nutrient metabolism or immunomodulatory. Both inflammatory bowel …

[HTML][HTML] A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation

HH Yang, JX Duan, SK Liu, JB Xiong, XX Guan… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Dysregulation of arachidonic acid (ARA) metabolism results in inflammation;
however, its role in acute lung injury (ALI) remains elusive. In this study, we addressed the …

ROS-responsive polymer nanoparticles with enhanced loading of dexamethasone effectively modulate the lung injury microenvironment

W Muhammad, J Zhu, Z Zhai, J Xie, J Zhou, X Feng… - Acta biomaterialia, 2022 - Elsevier
The acute lung injury (ALI) is an inflammatory disorder associated with cytokine storm, which
activates various reactive oxygen species (ROS) signaling pathways and causes severe …

Targeting receptor-interacting protein kinase 1 by novel benzothiazole derivatives: Treatment of acute lung injury through the necroptosis pathway

X Zhang, Q Han, R Hou, L Xu, W Zhang… - Journal of Medicinal …, 2023 - ACS Publications
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) are serious and
devastating pulmonary manifestations of acute systemic inflammation with high morbidity …

Targeted-lung delivery of dexamethasone using gated mesoporous silica nanoparticles. A new therapeutic approach for acute lung injury treatment

A García-Fernández, M Sancho, V Bisbal… - Journal of Controlled …, 2021 - Elsevier
Acute lung injury (ALI) is a critical inflammatory syndrome, characterized by increased
diffuse inflammation and severe lung damage, which represents a clinical concern due to …

Unravelling the therapeutic potential of nano-delivered functional foods in chronic respiratory diseases

DD Clarence, KR Paudel, B Manandhar, SK Singh… - Nutrients, 2022 - mdpi.com
Chronic inflammation of the respiratory tract is one of the most concerning public health
issues, as it can lead to chronic respiratory diseases (CRDs), some of which are more …

Curcumin attenuates airway inflammation and airway remolding by inhibiting NF-κB signaling and COX-2 in cigarette smoke-induced COPD mice

J Yuan, R Liu, Y Ma, Z Zhang, Z Xie - Inflammation, 2018 - Springer
The purpose of this study is to evaluate the therapeutic effects of curcumin on airway
inflammation using LPS and cigarette smoke (LC)-induced COPD murine models and LPS …

Ibudilast attenuates folic acid–induced acute kidney injury by blocking pyroptosis through TLR4-mediated NF-κB and MAPK signaling pathways

X Li, Y Zou, YY Fu, J Xing, KY Wang, PZ Wan… - Frontiers in …, 2021 - frontiersin.org
Folic acid (FA)-induced renal tubule damage, which is characterized by extensive
inflammation, is a common model of acute kidney injury (AKI). Pyroptosis, a pro …

Delivery systems of therapeutic nucleic acids for the treatment of acute lung injury/acute respiratory distress syndrome

C Zhuang, M Kang, M Lee - Journal of Controlled Release, 2023 - Elsevier
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a devastating
inflammatory lung disease with a high mortality rate. ALI/ARDS is induced by various …