Paramagnetic chemical probes have been used in electron paramagnetic resonance (EPR)
and nuclear magnetic resonance (NMR) spectroscopy for more than four decades. Recent …

Paramagnetic centers in biomolecules, such as specific metal ions that are bound to a
protein, affect the nuclei in their surrounding in various ways. One of these effects is the …

The scaffold protein p62/SQSTM1 is involved in protein turnover and signaling and is
commonly found in dense protein bodies in eukaryotic cells. In autophagy, p62 acts as a …

NMR spectroscopy is a key method for studying the structure and dynamics of (large)
multidomain proteins and complexes in solution. It plays a unique role in integrated …

Pseudocontact shifts in biomolecular NMR using paramagnetic metal tags Page 1 1
Pseudocontact shifts in biomolecular NMR using paramagnetic metal tags Christoph …

Abstract p62/SQSTM1 is an autophagy receptor and signaling adaptor with an N-terminal
PB1 domain that forms the scaffold of phase-separated p62 bodies in the cell. The molecular …

Clustering of macromolecules is a fundamental cellular device underlying diverse biological
processes that require high-avidity binding to effectors and substrates. Often, this involves a …

The presence of an unpaired electron in paramagnetic molecules generates significant
effects in NMR spectra, which can be exploited to provide restraints complementary to those …

Molecules containing unpaired electrons affect the magnetic properties of nuclei in their
vicinity, which is observable in Nuclear Magnetic Resonance (NMR) spectra. As these …

Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique for structural
studies of chemical compounds and biomolecules such as DNA and proteins. Since the …