Together with core histones, which make up the nucleosome, the linker histone (H1) is one
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …

Chromatin is a highly regulated nucleoprotein complex through which genetic material is
structured and maneuvered to elicit cellular processes, including transcription, cell division …

Chromatin is important for the regulation of transcription and other functions, yet the diversity
of chromatin composition and the distribution along chromosomes are still poorly …

MeCP2 is an abundant mammalian protein that binds to methylated CpG. We have found
that native and recombinant MeCP2 repress transcription in vitro from methylated promoters …

Gene regulation by steroid hormones has been a traditional field of research for biochemical
endocrinology since the discovery of puff induction by ecdysone in giant chromosomes of …

Background: The amplification of oncogenes in cancer cells is often mediated by paired
acentric chromatin bodies called double minute chromosomes (DMs), which can accumulate …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

Recent transcriptome analyses show that substantial proportions of eukaryotic genomes can
be copied into RNAs, many of which do not encode protein sequences. However, cells have …

Linker histone H1 plays an important role in chromatin folding in vitro. To study the role of H1
in vivo, mouse embryonic stem cells null for three H1 genes were derived and were found to …

Publisher Summary This chapter summarizes recent information on the function of high-
mobility-group (HMG) proteins. Advances in this field were made primarily by elucidating the …