Recent developments in next generation (S)-proline-derived chiral organocatalysts

E Juaristi - Tetrahedron, 2021 - Elsevier
In the area of asymmetric organocatalysis, significant effort has been dedicated during the
last decade to improve the performance of emblematic catalysts such as proline, as well as …

Recent applications of mechanochemistry in enantioselective synthesis

CG Avila-Ortiz, M Pérez-Venegas, J Vargas-Caporali… - Tetrahedron …, 2019 - Elsevier
In recent years, sustainable organocatalysis has become a relevant target in asymmetric
organic synthesis. Among the most successful strategies to achieve “greener” …

Asymmetric Aldol Reaction Organocatalyzed by (S)-Proline-Containing Dipeptides: Improved Stereoinduction under Solvent-Free Conditions

JG Hernandez, E Juaristi - The Journal of Organic Chemistry, 2011 - ACS Publications
The organocatalytic activity of the methyl ester of (S)-proline-(S)-phenylalanine,(S, S)-2, in
the asymmetric aldol reaction between cyclohexanone and acetone with various aromatic …

Solvent-free asymmetric aldol reaction organocatalyzed by (S)-proline-containing thiodipeptides under ball-milling conditions

JG Hernández, V García-López, E Juaristi - Tetrahedron, 2012 - Elsevier
An efficient, solvent-free ball-milling protocol for the asymmetric aldol reaction between
cyclohexanone and cyclopentanone with various aromatic aldehydes using a novel series of …

Efficient ball-mill procedure in the 'green'asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water

JG Hernández, E Juaristi - Tetrahedron, 2011 - Elsevier
The organocatalytic activity of (S)-proline-based dipeptides 1a–c has been evaluated in the
asymmetric aldol reaction between representative ketones with various aromatic aldehydes …

Enhancing the selectivity of prolinamide organocatalysts using the mechanical bond in [2] rotaxanes

M Calles, J Puigcerver, DA Alonso, M Alajarin… - Chemical …, 2020 - pubs.rsc.org
The synthesis of a pair of switchable interlocked prolinamides and their use as
organocatalysts in three different enamine-activated processes are reported. A …

Organocatalytic activity of α, α-dipeptide derivatives of (S)-proline in the asymmetric aldol reaction in absence of solvent. Evidence for non-covalent π–π interactions in …

E Machuca, E Juaristi - Tetrahedron Letters, 2015 - Elsevier
The trend in the magnitude of stereoselectivities observed in the asymmetric aldol reaction
between cyclohexanone and aromatic aldehydes with varying electron densities, catalyzed …

Iron‐and Bismuth‐Catalyzed Asymmetric Mukaiyama Aldol Reactions in Aqueous Media

T Kitanosono, T Ollevier… - Chemistry–An Asian …, 2013 - Wiley Online Library
We have developed asymmetric Mukaiyama aldol reactions of silicon enolates with
aldehydes catalyzed by chiral FeII and BiIII complexes. Although previous reactions often …

Synthesis of monoacylated derivatives of 1, 2-cyclohexanediamine. Evaluation of their catalytic activity in the preparation of Wieland− Miescher ketone

AL Fuentes de Arriba, DG Seisdedos… - The Journal of …, 2010 - ACS Publications
Ureas, carbamoyl derivatives, amides, and sulfonamides can be easily prepared from the
strained (R, R)-cylohexanediamine urea (1) in high yield, leaving a free amino group that …

Multifunctional “click” prolinamides: A new platform for asymmetric aldol reactions in the presence of water with catalyst recycling

S Paladhi, J Das, PK Mishra… - Advanced Synthesis & …, 2013 - Wiley Online Library
Abstract “Click” chemistry is combined with organocatalysis to fabricate a multifunctional C3‐
symmetrical dendritic prolinamide with a hydrophobic aromatic core and hydrophilic …