Measles remains a major cause of morbidity and mortality worldwide among vaccine
preventable diseases. Recent decline in vaccination coverage resulted in re-emergence of …

During the 1980s CD46 was discovered in a search for C3b binding proteins of human
peripheral blood cells. Its role as an inactivator of C3b and C4b deposited on self-tissue is …

The ability of cells to manage consequences of exogenous proteotoxicity is key to cellular
homeostasis. While a plethora of well-characterised machinery aids intracellular …

Autophagy is a highly regulated self-degradative mechanism required at a basal level for
intracellular clearance and recycling of cytoplasmic contents. Upon intracellular pathogen …

T cell shape is dictated by the selective recruitment of molecules to different regions of the
cell (polarity) and is integral to every aspect of T cell function, from migration to cytotoxicity …

Endocytosis supports cell communication, growth, and pathogen infection. The species B
human adenovirus serotype 3 (Ad3) is associated with epidemic conjunctivitis, and fatal …

The complement system is composed of soluble blood plasma proteins and cell membrane
proteins. A major function of the soluble complement proteins is to bind to and destroy …

The hemolytic uremic syndrome (HUS) is a triad of microangiopathic hemolytic anemia,
thrombocytopenia, and renal impairment. Genetic studies demonstrate that heterozygous …

Complement is undeniably quintessential for innate immunity by detecting and eliminating
infectious microorganisms. Recent work, however, highlights an equally profound impact of …

Macropinocytosis has long been known as a primary method for cellular intake of fluid-
phase and membrane-bound bulk cargo. This review seeks to re-examine the latest studies …