Mediator kinases CDK19 and CDK8, pleiotropic regulators of transcriptional reprogramming,
are differentially regulated by androgen signaling, but both kinases are upregulated in …

Given their central role in signal transduction, protein kinases (PKs) were first implicated in
cancer development, caused by aberrant intracellular signaling events. Since then, PKs …

CDK8 is an important member of the cyclin-dependent kinase family associated with
transcription and acts as a key “molecular switch” in the Mediator complex. CDK8 regulates …

Simple Summary The prognosis for patients with relapsed neuroblastoma is poor, and novel
treatment options for these patients are needed. Some relapsed neuroblastoma tumors …

Triple-negative breast cancers (TNBC) are treated primarily by chemotherapy and lack
clinically validated therapeutic targets. In particular, inhibitors of the PI3K/AKT/mTOR …

Neuroblastoma (NB) is a severe pediatric tumor originating from the developing sympathetic
nervous system, characterized by diverse clinical outcomes, including spontaneous …

Castration-resistant prostate cancer (CRPC) remains incurable due to its high plasticity. We
found that Mediator kinases CDK8 and CDK19, pleiotropic regulators of transcriptional …

Hyperactivation of the immune system remains a dramatic, life-threatening complication of
viral and bacterial infections, particularly during pneumonia. Therapeutic approaches to …

Despite numerous efforts, the therapeutic advancement for neuroblastoma and other cancer
treatments is still ongoing due to multiple challenges, such as the increasing prevalence of …

Hyperactivation of the immune system remains a dramatic, life-threatening complication of
viral and bacterial infections, particularly during pneumonia. Therapeutic approaches to …