The use of deuteration in medicinal chemistry has exploded in the past years, and the FDA
has recently approved the first deuterium-labeled drug. Precision deuteration goes beyond …

Mitochondria are key cell organelles in that they are responsible for energy production and
control many processes from signalling to cell death. The function of the mitochondrial …

In addition to ATP synthesis, mitochondria are highly dynamic organelles that modulate
apoptosis, ferroptosis, and inflammasome activation. Through executing these varied …

The past decade has yielded tremendous insights into how cells die. This has come with our
understanding that several distinct forms of cell death are encompassed under the umbrella …

Iron accumulation is a key mediator of several cytotoxic mechanisms leading to the
impairment of redox homeostasis and cellular death. Iron overload is often associated with …

Iron accumulation has been associated with the etiology and progression of multiple
neurodegenerative diseases (NDDs). The exact role of iron in these diseases is not fully …

Increased reactive oxygen species production and oxidative stress have been implicated in
the pathogenesis of numerous neurodegenerative conditions including among others …

Mitochondria not only supply the energy for cell function, but also take part in cell signaling.
This review describes the dysfunctions of mitochondria in aging and neurodegenerative …

Mitochondrial dysfunction is reiteratively involved in the pathogenesis of diverse
neurodegenerative diseases. Current in vitro and in vivo approaches support that …

Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …