In the past few decades, cardiac regeneration has been the central target for restoring the
injured heart. In mammals, cardiomyocytes are terminally differentiated and rarely divide …

Because of remarkable surgical and medical advances over the past several decades, there
are growing numbers of infants and children living with single ventricle congenital heart …

Background: NOTCH1 pathogenic variants are implicated in multiple types of congenital
heart defects including hypoplastic left heart syndrome, where the left ventricle is …

Congenital heart disease is the most common congenital defect observed in newborns.
Within the spectrum of congenital heart disease are left‐sided obstructive lesions (LSOLs) …

Congenital heart defects account for 1% of infant mortality and 10% of in utero deaths. As
the vertebrate embryo develops, multiple tissue types develop in tandem to morphologically …

Congenital heart disease (CHD) is the most common cause of infant death associated with
birth defects. Recent next-generation genome sequencing has uncovered novel genetic …

Abstract Hypoplastic Left Heart Syndrome (HLHS) is a complex Congenital Heart Disease
(CHD) that was almost universally fatal until the advent of the Norwood operation in 1981 …

The NOTCH signalling pathway is an essential pathway, involved in many cellular
processes, including cell fate decision, cell proliferation, and cell death and important in the …

Congenital heart defects (CHD) are the most common congenital anomalies in liveborn
children. In contrast to syndromic CHD (SCHD), the genetic basis of isolated CHD (ICHD) is …

Congenital heart disease (CHD) is one of the most prevalent neonatal congenital
anomalies. To catalog the putative candidate CHD risk genes, we collected 16,349 variants …