The brain is unique among organs in many respects, including its mechanisms of lipid
synthesis and energy production. The nervous system-specific metabolite N-acetylaspartate …

Huntington's disease (HD) is a neurodegenerative disorder caused by a mutation in the
gene encoding Huntingtin. The mechanisms underlying the preferential degeneration of the …

N-Acetylaspartate (NAA) is employed as a non-invasive marker for neuronal health using
proton magnetic resonance spectroscopy (MRS). This utility is afforded by the fact that NAA …

Over the last few years, awareness of autism spectrum disorder (ASD) in adults has
increased. The precise etiology of ASD is still unresolved. Animal research, genetic and …

Background Alzheimer's disease (AD) is the most common form of dementia, and it affects
more women than men. Mitochondrial dysfunction (MD) plays a key role in AD, and it is …

OBJECTIVE: The authors examined the effect of the acetylcholinesterase inhibitor donepezil
on magnetic resonance markers of neurodegeneration in Alzheimer's disease. METHOD: In …

To evaluate the contribution of cellular dysfunction and neuronal loss to brain N‐
acetylaspartate (NAA) depletion, NAA was measured in brain tissue by HPLC and UV …

Alzheimer's disease (AD) is the most common cause of adult dementia. Yet the complete set
of molecular changes accompanying this inexorable, neurodegenerative disease remains …

This study aims to determine the relationship among cerebral metabolite concentrations (on
proton magnetic resonance spectroscopy or 1H MRS), cognitive function, and clinical …

Attention-deficit/hyperactivity disorder (ADHD) is characterized by a pattern of chronic
symptoms including inattention and hyperactivity–impulsivity. Most individuals with ADHD …