[HTML][HTML] Targeting inflammation in atherosclerosis—from experimental insights to the clinic

O Soehnlein, P Libby - Nature reviews Drug discovery, 2021 - nature.com
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …

[HTML][HTML] Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

W Chen, M Schilperoort, Y Cao, J Shi, I Tabas… - Nature Reviews …, 2022 - nature.com
Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis
and contribute to the development of novel diagnostic and therapeutic strategies to further …

Macrophages in atherosclerosis: a dynamic balance

KJ Moore, FJ Sheedy, EA Fisher - Nature Reviews Immunology, 2013 - nature.com
Atherosclerosis is a chronic inflammatory disease that arises from an imbalance in lipid
metabolism and a maladaptive immune response driven by the accumulation of cholesterol …

Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis

PY Chen, L Qin, G Li, Z Wang, JE Dahlman… - Nature …, 2019 - nature.com
Atherosclerosis is a progressive vascular disease triggered by interplay between abnormal
shear stress and endothelial lipid retention. A combination of these and, potentially, other …

Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint

TT Tang, X Cheng, B Truong, LZ Sun, XF Yang… - Pharmacology & …, 2021 - Elsevier
The CD40 receptor and its ligand CD40L is one of the most critical molecular pairs of the
stimulatory immune checkpoints. Both CD40 and CD40L have a membrane form and a …

[HTML][HTML] Biological drug and drug delivery-mediated immunotherapy

Q Xiao, X Li, Y Li, Z Wu, C Xu, Z Chen, W He - Acta Pharmaceutica Sinica B, 2021 - Elsevier
The initiation and development of major inflammatory diseases, ie, cancer, vascular
inflammation, and some autoimmune diseases are closely linked to the immune system …

[HTML][HTML] Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases

J Yang, L Zhang, C Yu, XF Yang, H Wang - Biomarker research, 2014 - Springer
Monocytes express various receptors, which monitor and sense environmental changes.
Monocytes are highly plastic and heterogeneous, and change their functional phenotype in …

Inflammation and its resolution as determinants of acute coronary syndromes

P Libby, I Tabas, G Fredman, EA Fisher - Circulation research, 2014 - Am Heart Assoc
Inflammation contributes to many of the characteristics of plaques implicated in the
pathogenesis of acute coronary syndromes. Moreover, inflammatory pathways not only …

Atherosclerosis: current pathogenesis and therapeutic options

C Weber, H Noels - Nature medicine, 2011 - nature.com
Coronary artery disease (CAD) arising from atherosclerosis is a leading cause of death and
morbidity worldwide. The underlying pathogenesis involves an imbalanced lipid metabolism …

Anticytokine agents: targeting interleukin signaling pathways for the treatment of atherothrombosis

PM Ridker - Circulation research, 2019 - Am Heart Assoc
The recognition that atherosclerosis is a complex chronic inflammatory disorder mediated
through both adaptive and innate immunity has led to the hypothesis that anticytokine …