[HTML][HTML] Targeting inflammation in atherosclerosis—from experimental insights to the clinic
O Soehnlein, P Libby - Nature reviews Drug discovery, 2021 - nature.com
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …
inflammation from its inception to the emergence of complications. Targeting inflammatory …
[HTML][HTML] Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis
Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis
and contribute to the development of novel diagnostic and therapeutic strategies to further …
and contribute to the development of novel diagnostic and therapeutic strategies to further …
Macrophages in atherosclerosis: a dynamic balance
Atherosclerosis is a chronic inflammatory disease that arises from an imbalance in lipid
metabolism and a maladaptive immune response driven by the accumulation of cholesterol …
metabolism and a maladaptive immune response driven by the accumulation of cholesterol …
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis
Atherosclerosis is a progressive vascular disease triggered by interplay between abnormal
shear stress and endothelial lipid retention. A combination of these and, potentially, other …
shear stress and endothelial lipid retention. A combination of these and, potentially, other …
Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint
The CD40 receptor and its ligand CD40L is one of the most critical molecular pairs of the
stimulatory immune checkpoints. Both CD40 and CD40L have a membrane form and a …
stimulatory immune checkpoints. Both CD40 and CD40L have a membrane form and a …
[HTML][HTML] Biological drug and drug delivery-mediated immunotherapy
The initiation and development of major inflammatory diseases, ie, cancer, vascular
inflammation, and some autoimmune diseases are closely linked to the immune system …
inflammation, and some autoimmune diseases are closely linked to the immune system …
[HTML][HTML] Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases
Monocytes express various receptors, which monitor and sense environmental changes.
Monocytes are highly plastic and heterogeneous, and change their functional phenotype in …
Monocytes are highly plastic and heterogeneous, and change their functional phenotype in …
Inflammation and its resolution as determinants of acute coronary syndromes
Inflammation contributes to many of the characteristics of plaques implicated in the
pathogenesis of acute coronary syndromes. Moreover, inflammatory pathways not only …
pathogenesis of acute coronary syndromes. Moreover, inflammatory pathways not only …
Atherosclerosis: current pathogenesis and therapeutic options
Coronary artery disease (CAD) arising from atherosclerosis is a leading cause of death and
morbidity worldwide. The underlying pathogenesis involves an imbalanced lipid metabolism …
morbidity worldwide. The underlying pathogenesis involves an imbalanced lipid metabolism …
Anticytokine agents: targeting interleukin signaling pathways for the treatment of atherothrombosis
PM Ridker - Circulation research, 2019 - Am Heart Assoc
The recognition that atherosclerosis is a complex chronic inflammatory disorder mediated
through both adaptive and innate immunity has led to the hypothesis that anticytokine …
through both adaptive and innate immunity has led to the hypothesis that anticytokine …