In dramatic contrast to the poor repair outcomes for humans and rodent models such as
mice, salamanders and some fish species are able to completely regenerate heart tissue …

Cardiomyocyte regeneration following cardiac damage is challenging to study because of
the inflammatory process, the multiplication of cells in the stroma, and the creation of scar …

Although stem/progenitor cell therapy shows potential for myocardial infarction repair,
enhancing the therapeutic efficacy could be achieved through additional genetic …

ABSTRACT Parkinson's disease (PD), the second common neurodegenerative disease, is
characterized by the loss of the dopaminergic neurons in the substantia nigra (SN). Because …

Adult mammalian hearts show limited capacity to proliferate after injury, while zebrafish are
capable to completely regenerate injured hearts through the proliferation of spared …

Abstract Study Objectives Chronic intermittent hypoxia (CIH) is a major determinant in
obstructive sleep apnea cardiovascular morbidity and this effect is influenced by age. The …

Bone mesenchymal stem cells (BMSCs) transplantation is a promising therapeutic approach
for myocardial infarction (MI), but its application is limited by poor viability of BMSCs. In this …

Arrhythmogenic cardiomyopathy (AC) is a familial cardiac disorder at high risk of arrhythmic
sudden death in the young and athletes. AC is hallmarked by myocardial replacement with …

Highlights•Adult stem cells have limited cardiomyocyte (CM) potential.•Pluripotent stem cells
(PSCs) differentiate into CMs using defined factors.•Regenerative potential of PSC-CMs has …

Although the field of cardiac regeneration is relatively young, it is progressing rapidly with
technological advancements. Genome editing tools are allowing researchers to creatively …