The brain's default network: anatomy, function, and relevance to disease
RL Buckner, JR Andrews‐Hanna… - Annals of the new York …, 2008 - Wiley Online Library
Thirty years of brain imaging research has converged to define the brain's default network—
a novel and only recently appreciated brain system that participates in internal modes of …
a novel and only recently appreciated brain system that participates in internal modes of …
Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease
Recent evidence suggests that some brain areas act as hubs interconnecting distinct,
functionally specialized systems. These nexuses are intriguing because of their potential …
functionally specialized systems. These nexuses are intriguing because of their potential …
Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer's disease
MV Guillot-Sestier, AR Araiz, V Mela, AS Gaban… - Communications …, 2021 - nature.com
Age and sex are major risk factors in Alzheimer's disease (AD) with a higher incidence of the
disease in females. Neuroinflammation, which is a hallmark of AD, contributes to disease …
disease in females. Neuroinflammation, which is a hallmark of AD, contributes to disease …
Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory
RL Buckner, AZ Snyder, BJ Shannon… - Journal of …, 2005 - Soc Neuroscience
Alzheimer's disease (AD) and antecedent factors associated with AD were explored using
amyloid imaging and unbiased measures of longitudinal atrophy in combination with …
amyloid imaging and unbiased measures of longitudinal atrophy in combination with …
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) influences cytotoxicity,
translocating to the nucleus during apoptosis. Here we report a signalling pathway in which …
translocating to the nucleus during apoptosis. Here we report a signalling pathway in which …
Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition
AG Vlassenko, SN Vaishnavi… - Proceedings of the …, 2010 - National Acad Sciences
Amyloid-β (Aβ) plaque deposition can precede the clinical manifestations of dementia of the
Alzheimer type (DAT) by many years and can be associated with changes in brain …
Alzheimer type (DAT) by many years and can be associated with changes in brain …
Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden
A Drzezga, JA Becker, KRA Van Dijk, A Sreenivasan… - Brain, 2011 - academic.oup.com
Disruption of functional connectivity between brain regions may represent an early
functional consequence of β-amyloid pathology prior to clinical Alzheimer's disease. We …
functional consequence of β-amyloid pathology prior to clinical Alzheimer's disease. We …
Confidence intervals for predictive values with an emphasis to case–control studies
ND Mercaldo, KF Lau, XH Zhou - Statistics in medicine, 2007 - Wiley Online Library
The accuracy of a binary‐scale diagnostic test can be represented by sensitivity (Se),
specificity (Sp) and positive and negative predictive values (PPV and NPV). Although Se …
specificity (Sp) and positive and negative predictive values (PPV and NPV). Although Se …
On the functional diversity of glyceraldehyde-3-phosphate dehydrogenase: biochemical mechanisms and regulatory control
MA Sirover - Biochimica et Biophysica Acta (BBA)-General Subjects, 2011 - Elsevier
Background New studies provide evidence that glyceraldehyde-3-phosphate
dehydrogenase (GAPDH) is not simply a classical glycolytic protein of little interest. Instead …
dehydrogenase (GAPDH) is not simply a classical glycolytic protein of little interest. Instead …