Ethanol is one of the most commonly abused drugs. Although environmental and genetic
factors contribute to the etiology of alcohol use disorders, it is ethanol's actions in the brain …

Abstract gamma-Aminobutyric acid (GABA)-mediated inhibitory neurotransmission and the
gene products involved were discovered during the mid-twentieth century. Historically …

Over the past two decades, research has identified extrasynaptic GABA A receptor
populations that enable neurons to sense the low ambient GABA concentrations present in …

The proper functioning of the adult mammalian brain relies on the orchestrated regulation of
neural activity by a diverse population of GABA (γ-aminobutyric acid)-releasing neurons …

Background Methanol poisoning (MP) occurs often via ingestion, inhalation, or dermal
exposure to formulations containing methanol in base. Clinical manifestations of MP include …

The past decade has brought many advances in our understanding of GABA A receptor-
mediated ethanol action in the central nervous system. We now know that specific GABA A …

Alcohol is among the most widely used psychoactive substances worldwide. Ethanol
metabolites such as acetate, thought to be primarily the result of ethanol breakdown by …

It was shown recently that exposure of the developing rat brain during the peak of
synaptogenesis to commonly used general anesthetics can trigger widespread apoptotic …

Neuronal mechanisms underlying alcohol intoxication are unclear. We find that alcohol
impairs motor coordination by enhancing tonic inhibition mediated by a specific subtype of …

GABAergic inhibitory transmission is involved in the acute and chronic effects of ethanol on
the brain and behavior. One-dose ethanol exposure induces transient plastic changes in …