Traumatic brain injury (TBI) is an intracranial injury caused by accidents, falls, or sports. The
production of endothelins (ETs) is increased in the injured brain. ET receptors are classified …

Brain injury poses a heavy disease burden in the world, resulting in chronic deficits.
Therapies for brain injuries have been focused on pharmacologic, small molecule …

Hallmark pathological features of brain trauma are axonal degeneration and demyelination
because myelin-producing oligodendrocytes (OLs) are particularly vulnerable to injury …

Aims: To determine the efficacy of XPro1595 to improve pathophysiological and functional
outcomes in a mouse model of traumatic brain injury (TBI). Background: Symptoms …

Background Symptoms associated with acute pancreatitis can be debilitating, and treatment
remains a challenge. This study aimed to investigate the efficacy of selectively inhibiting the …

Traumatic brain injury (TBI) is a major health problem causing disability and death
worldwide. There is no effective treatment, due in part to the complexity of the injury …

Clinical trials examining neuroprotective strategies after brain injury, including those
targeting cell death mechanisms, have been underwhelming. This may be in part due to an …

Ephrin family proteins are cell surface molecules that regulate several cellular functions
through cell-cell interactions. During nervous tissue repair after injury, the expression of …

The subventricular zone (SVZ) in the mammalian forebrain contains stem/progenitor cells
that migrate through the rostral migratory stream (RMS) to the olfactory bulb throughout …

According to the World Health Organization, by the year 2020 traumatic brain injury (TBI) will
surpass many diseases to become the leading cause of patient death and disability …