Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been
reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic …

Abstract Purpose Amorphous solid dispersions (ASDs) have been widely used in the
pharmaceutical industry for solubility enhancementof poorly water-soluble drugs. The …

Over the last half-century, solid dispersions (SDs) have been intensively investigated as a
strategy to improve drugs solubility and dissolution rate, enhancing oral bioavailability. In …

The goal of this study was to use polymeric konjac glucomannan (KGM), Kollidon VA 64
(KVA64), and glutaraldehyde to ameliorate stomach specific floating microspheres (SSFM) …

Piroxicam (PRM) and meloxicam (MEL) are two nonsteroidal anti-inflammatory drugs,
belonging to the Biopharmaceutics Classification System Class II drugs. In this study, six …

At present, saccharides as hydrophilic matrixes, have been gradually used in amorphous
solid dispersions (ASD) for dispersing poorly water-soluble drugs without surfactants. In this …

This study aimed to formulate and optimize solid-dispersion of meloxicam (MX) employing
response-surface-methodology (RSM). RSM allowed identification of the main effects and …

Puerarin (PUE) is a Chinese traditional medicine known to enhance glucose uptake into the
insulin cells to downregulate the blood glucose levels in the treatment of type II diabetes …

H ost-guest inclusion complexes have been extensively studied for drug delivery
applications. The host molecule, typically cyclodextrin, creates a cavity, in which the guest …

Amorphicity is one possible way to increase the solubility of poorly water soluble drugs.
However, amorphous solids are thermodynamically unstable and tend to recrystallize with …