MicroRNAs (miRNAs) are initially expressed as long transcripts that are processed in the
nucleus to yield∼ 65-nucleotide (nt) RNA hairpin intermediates, termed pre-miRNAs, that …

MicroRNAs (miRNAs) function as 21–24 nucleotide guide RNAs that use partial base-
pairing to recognize target messenger RNAs and repress their expression. As a large …

The structure, function and reactions of nucleic acids are central to molecular biology and
are crucial for the understanding of complex biological processes involved. Revised and …

Nuclear transport of proteins and RNA occurs through the nuclear pore complex and is
mediated by a superfamily of transport receptors known collectively as karyopherins …

Macromolecular transport between the cytoplasm and the nucleus occurs through the
nuclear pore complex (NPC) and is mediated by multiple families of soluble transport …

The only mammalian RNA binding adapter proteins known to partner with TAP/NXF1, the
primary receptor for general mRNA export, are members of the REF family. We demonstrate …

In eukaryotic cells, the enclosure of the genetic information in the nucleus allows the spatial
and temporal separation of DNA replication and transcription from cytoplasmic protein …

The eukaryotic nucleus is surrounded by a protective nuclear envelope, which is perforated
by trafficking machines termed nuclear pore complexes (NPCs). The NPCs are the sole …

The discovery of microRNAs (miRNAs) has changed the paradigm of gene regulation,
leaving us with numerous exciting questions regarding what these molecules do and how …

Over the past two years, it has become evident that there is an unexpected link between
nuclear pore complex structure and dynamics, nucleocytoplasmic transport and …