A growing body of evidence supports the notion that epigenetic changes such as DNA
methylation and histone modifications, both involving chromatin remodeling, contribute to …

Insufficient oxygen availability (hypoxia) is a precursor to numerous cardiovascular
diseases, including atherosclerosis, pulmonary hypertension, and heart failure. The main …

Molecular oxygen (O2) plays a key role in many physiological processes, and becomes a
toxicant to kill cells when excited to 1O2. Intracellular O2 levels, or the degree of hypoxia …

Real-time monitoring of the contents of molecular oxygen (O2) in tumor cells is of great
significance in early diagnosis of cancer. At the same time, the photodynamic therapy (PDT) …

Purpose The aim of the present study was to investigate the in vivo effects of dietary medium-
chain triglyceride (MCT) on inflammation and insulin resistance as well as the underlying …

Irisin is a myokine regulated by peroxisome proliferator-activated receptor gamma co-
activator-1α (PGC-1α) in the exercising skeletal muscle and released into the bloodstream …

Obesity is associated with tissue hypoxia and the up-regulation of hypoxia inducible factor 1
alpha (HIF-1α). Prior studies in transgenic mice have shown that HIF-1α plays a role in the …

Insulin resistance is a key defect associated with obesity, type 2 diabetes and other
metabolic diseases. While a number of factors have been suggested to cause defects in …

Hypoxia signaling plays an important role in physiological and pathological conditions.
Hypoxia in the heart tissue can produce different consequences depending on the duration …

Mangiferin, a xanthone glucoside, and its associated traditional herbs have been
demonstrated to improve abnormalities of lipid metabolism. However, its underlying …