In the present work, we report compilation and analysis of 245 drugs, including small and
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …

Over the last two decades, fluorine substitution has become one of the essential structural
traits in modern pharmaceuticals. Thus, about half of the most successful drugs (blockbuster …

Approximately 40% of the world population live in areas with the risk of malaria. Each year,
300–500 million people suffer from acute malaria, and 0.5–2.5 million die from the disease …

Primaquine was firstly synthesized in 1946 in the USA, and is the most representative
member of the anti-malarial 8-aminoquinolines. Six decades have passed and primaquine …

New drugs against malaria are greatly needed. Many approaches to antimalarial drug
discovery are available. These approaches must take into account specific concerns, in …

The technical genesis and practice of 8-aminoquinoline therapy of latent malaria offer
singular scientific, clinical, and public health insights. The 8-aminoquinolines brought …

Over the past decade, there has been a transformation in the portfolio of medicines to
combat malaria. New fixed-dose artemisinin combination therapy is available, with four …

Background In malaria endemic areas, pre‐school children are at high risk of severe and
repeated malaria illness. One possible public health strategy, known as Intermittent …

Background A drug for causal (ie, pre-erythrocytic) prophylaxis of Plasmodium falciparum
malaria with prolonged activity would substantially advance malaria control. DSM265 is an …

Abstract We tested tafenoquine (WR 238605), a new long-acting 8-aminoquinoline, for its
ability to prevent malaria in an area that is holoendemic for Plasmodium falciparum. In a …