Both cardiovascular disease and aging are associated with changes in the sympathetic
nervous system. Indeed, mounting evidence indicates that adrenergic receptors are …

Activation of the adrenergic system has a profound effects on metabolism. Increased
circulating catecholamine and activation of the different adrenergic receptors deployed in …

There is an increasing worldwide epidemic of type 2 diabetes that poses major health
problems. We have identified a novel physiological system that increases glucose uptake in …

SCFA are produced in the gut by bacterial fermentation of undigested carbohydrates.
Activation of the Gαi-protein-coupled receptor GPR41 by SCFA in β-cells and sympathetic …

Activation of the sympathetic nervous system causes pronounced metabolic changes that
are mediated by multiple adrenergic receptor subtypes. Systemic treatment with β2 …

Abstract β 3-Adrenoceptor agonists were originally considered as a promising drug class for
the treatment of obesity and/or type 2 diabetes. When these development efforts failed, they …

G protein–coupled receptors (GPCRs) are the largest class of cell surface signaling proteins,
participate in nearly all physiological processes, and are the targets of 30% of marketed …

This chapter will review the essential properties of adrenergic receptors in the physiology of
cardiac function and in the pathology of cardiovascular disease. Following a systematic …

Prolonged supplementation with the β2-agonist clenbuterol improves glucose homeostasis
in diabetic rodents, likely via β2-adrenoceptor (β2-AR)-mediated effects in the skeletal …

The type 2 diabetes epidemic makes it important to find insulin-independent ways to
improve glucose homeostasis. This study examines the mechanisms activated by a dual β2 …