Type 1 diabetes is an autoimmune disease characterised by the destruction of insulin
producing beta cells in the pancreas. Whilst it remains unclear what the original triggering …

Abbreviations: NDDG, National Diabetes Data Group; WHO, World Health Organization;
CVD, cardiovascular disease; ADA, American Diabetes Association; IFG, impaired fasting …

Background Glutamic acid decarboxylase (GAD) is a major target of the autoimmune
response that occurs in type 1 diabetes mellitus. In animal models of autoimmunity …

Background The 65-kD isoform of glutamic acid decarboxylase (GAD) is a major
autoantigen in patients with type 1 diabetes mellitus. This trial assessed the ability of alum …

Growing insight into the pathogenesis of type 1 diabetes (T1D) and numerous studies in
preclinical models highlight the potential of antigen-specific approaches to restore tolerance …

NOD mice deficient for B lymphocytes from birth fail to develop autoimmune or type 1
diabetes. To assess whether B cell depletion influences type 1 diabetes in mice with an …

The purpose of this Phase II study was to evaluate if alum-formulated human recombinant
GAD65 is safe and does not compromise beta cell function. The study was conducted as a …

Type 1 diabetes mellitus (T1DM) is the result of autoimmune destruction of pancreatic β cells
in genetically predisposed individuals with impaired immune regulation. The insufficiency in …

Normal levels of CD4+ regulatory T cells are critical for the maintenance of immunological
homeostasis and the prevention of autoimmune diseases. However, we now show that the …

Type 1 diabetes (T1D) is a chronic autoimmune disorder characterized by destruction of
insulin-producing pancreatic β cells. Many broad-based immunosuppressive and antigen …