Although it is most well-known for its roles in central nervous system (CNS) function, the vast
majority of serotonin, or 5-hydroxytryptamine (5-HT), is produced in the gastrointestinal (GI) …

Disorders of gut-brain interaction (DGBIs) are common conditions in community and clinical
practice. As specialized enteroendocrine cells, enterochromaffin (EC) cells produce up to …

Oxidative stress, which can be activated by a variety of environmental risk factors, has been
implicated as an important pathogenic factor for inflammatory bowel disease (IBD) …

Dynamic interactions between gut mucosal cells and the external environment are essential
to maintain gut homeostasis. Enterochromaffin (EC) cells transduce both chemical and …

Gastrointestinal motility is tightly regulated by the enteric nervous system (ENS). Disruption
of coordinated enteric nervous system activity can result in dysmotility. Pharmacological …

Background Increasing age increases the incidence of chronic constipation and fecal
impaction. The contribution of the natural aging process to this phenotype is unclear. This …

The interaction of nutrients and bacterial-derived products and their enteroendocrine effects
are still enigmatic. We used the human enteroendocrine tumour cell line P-STS isolated from …

Introduction Short bowel syndrome is a devastating gastrointestinal disorder in which
decreased bowel length results in inadequate absorption causing nutritional deficiencies …

The colon performs several important functions. All of them are performed with the
participation of smooth muscle tissue of the intestinal wall and require optimal …

Visceral pain, a debilitating hallmark of disorders of gut-brain axis interactions such as
irritable bowel syndrome, has a major impact on quality of life. Given the increasing …