To address the continued rise of multi-drug-resistant microorganisms, the development of
novel drugs with new modes of action is urgently required. While humans biosynthesize the …

The MEP (Methyl Erythritol Phosphate) isoprenoids biosynthesis pathway is an attractive
drug target to combat malaria, due to its uniqueness and indispensability for the parasite. It …

Severe malaria due to Plasmodium falciparum remains a significant global health threat.
DXR, the second enzyme in the MEP pathway, plays an important role to synthesize building …

In Mycobacterium tuberculosis (Mtb) and Plasmodium falciparum (Pf), the methylerythritol
phosphate (MEP) pathway is responsible for isoprene synthesis. This pathway and its …

The ESKAPE pathogens comprise a group of multidrug-resistant bacteria that are the
leading cause of nosocomial infections worldwide. The prevalence of antibiotic resistant …

Despite continued research efforts, the threat of drug resistance from a variety of bacteria
continues to plague clinical communities. Discovery and validation of novel biochemical …

Deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is the first committed enzyme in the
2-methyl-D-erythritol 4-phosphate (MEP) terpenoid biosynthetic pathway and is also a …

Plants synthesize a large number of isoprenoids that are of nutritional, medicinal and
industrial importance. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) catalyzes …

Malaria is a global health threat that requires immediate attention. Malaria is caused by the
protozoan parasite Plasmodium, the most severe form of which is Plasmodium falciparum …

In this review, we analyze the enzyme DXS, the first and rate-limiting protein in the
methylerythritol 4-phosphate pathway. This pathway was discovered in 1996 and is one of …