CK2 is a multitask kinase whose role is essential for a countless number of cellular
processes, many of which are critical for blood cell development. A prevailing task for this …

The rates of ribosome production by a nucleolus and of protein biosynthesis by ribosomes
are tightly correlated with the rate of cell growth and proliferation. All these processes must …

Triple negative breast cancer (TNBC) remains challenging because of heterogeneous
responses to chemotherapy. Incomplete response is associated with a greater risk of …

The quality of the adaptive immune response depends on the differentiation of distinct CD4+
helper T cell subsets, and the magnitude of an immune response is controlled by CD4+ …

Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that
phosphorylates a large number of substrates, resulting in increased cell proliferation and …

Transcription initiation factor I (TIF-IA) plays an essential role in regulating ribosomal RNA
(rRNA) synthesis by tethering RNA polymerase I (Pol I) to the rDNA promoter. We have …

Protein kinase CK2 is a Ser/Thr protein kinase that phosphorylates hundreds of substrates
mainly related to survival and proliferation pathways. It has long been considered an anti …

Background The epithelial-to-mesenchymal transition (EMT) is a major phenotype of cancer
metastasis and invasion. As a druggable cancer target, the inhibition of protein kinase CK2 …

Apoptosis of alveolar macrophages following Mycobacterium tuberculosis infection have
been demonstrated to play a central role in the pathogenesis of tuberculosis. In the present …

Structurally, protein kinase CK2 consists of two catalytic subunits (α and α′) and two
regulatory subunits (β), which play a critical role in targeting specific CK2 substrates …