Noncoding RNA therapeutics—challenges and potential solutions

M Winkle, SM El-Daly, M Fabbri, GA Calin - Nature reviews Drug …, 2021 - nature.com
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …

A review of computational drug repositioning: strategies, approaches, opportunities, challenges, and directions

TN Jarada, JG Rokne, R Alhajj - Journal of cheminformatics, 2020 - Springer
Drug repositioning is the process of identifying novel therapeutic potentials for existing drugs
and discovering therapies for untreated diseases. Drug repositioning, therefore, plays an …

Trends in the development of miRNA bioinformatics tools

L Chen, L Heikkinen, C Wang, Y Yang… - Briefings in …, 2019 - academic.oup.com
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression via
recognition of cognate sequences and interference of transcriptional, translational or …

Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets

T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

EVmiRNA: a database of miRNA profiling in extracellular vesicles

T Liu, Q Zhang, J Zhang, C Li, YR Miao… - Nucleic Acids …, 2019 - academic.oup.com
Extracellular vesicles (EVs), such as exosomes and microvesicles, acted as cell-to-cell
communication vectors and potential biomarkers for diseases. microRNAs (miRNAs) are the …

RNAInter in 2020: RNA interactome repository with increased coverage and annotation

Y Lin, T Liu, T Cui, Z Wang, Y Zhang, P Tan… - Nucleic acids …, 2020 - academic.oup.com
Research on RNA-associated interactions has exploded in recent years, and increasing
numbers of studies are not limited to RNA–RNA and RNA–protein interactions but also …

A survey of current trends in computational drug repositioning

J Li, S Zheng, B Chen, AJ Butte… - Briefings in …, 2016 - academic.oup.com
Computational drug repositioning or repurposing is a promising and efficient tool for
discovering new uses from existing drugs and holds the great potential for precision …

miRNet-dissecting miRNA-target interactions and functional associations through network-based visual analysis

Y Fan, K Siklenka, SK Arora, P Ribeiro… - Nucleic acids …, 2016 - academic.oup.com
MicroRNAs (miRNAs) can regulate nearly all biological processes and their dysregulation is
implicated in various complex diseases and pathological conditions. Recent years have …

HMDD v2. 0: a database for experimentally supported human microRNA and disease associations

Y Li, C Qiu, J Tu, B Geng, J Yang, T Jiang… - Nucleic acids …, 2014 - academic.oup.com
Abstract The Human microRNA Disease Database (HMDD; available via the Web site at
http://cmbi. bjmu. edu. cn/hmdd and http://202.38. 126.151/hmdd/tools/hmdd2. html) is a …

MicroRNA regulatory network analysis using miRNet 2.0

L Chang, J Xia - Transcription factor regulatory networks, 2022 - Springer
MicroRNAs exert their effects in the context of gene regulatory networks. The recent
development of high-throughput experimental approaches and the growing availability of …