Importance Ketamine hydrochloride is increasingly used to treat depression and other
psychiatric disorders but can induce schizophrenia-like or psychotomimetic symptoms …

Accumulating research demonstrates the potential of intranasal delivery of
psychopharmacological agents to treat a range of psychiatric disorders and symptoms. It is …

Background The N-methyl-D-aspartate glutamate receptor antagonist ketamine, delivered
via an intravenous route, has shown rapid antidepressant effects in patients with treatment …

BACKGROUND: Ketamine has rapid antidepressant effects lasting as long as 1 week in
patients with major depressive disorder (MDD) and bipolar depression (BD). Ketamine is …

Ketamine, an N-methyl-D-aspartate receptor (NMDAR) channel blocker, has been found to
induce rapid and robust antidepressant-like effects in rodent models and in treatment …

Major depressive disorder is a complex multifactorial condition with a so far poorly
characterized underlying pathophysiology. Consequently, the available treatments are far …

Over 20 years ago, Deakin and Graeff hypothesized about the role of different serotonergic
pathways in controlling the behavioral and physiologic responses to aversive stimuli, and …

Ketamine is an effective antidepressant, but there is substantial variability in patient
response and the precise mechanism of action is unclear. Neuroimaging can provide …

The rapid antidepressant effect of ketamine has become a breakthrough in the research and
treatment of depression. Although predictive and modulating factors of the response to …

Aims: This study was designed to evaluate the changes in EEG power spectra and EEG
coherence in a ketamine model of psychosis in rats. Analyses of behavioral measurements …