Many replication origins that are licensed by loading MCM2-7 complexes in G1 are not
normally used. Activation of these dormant origins during S phase provides a first line of …

The greatest difference between species is size; however, the developmental mechanisms
determining organism growth remain poorly understood. Primordial dwarfism is a group of …

Aneuploidy is a hallmark of cancer and underlies genetic disorders characterized by severe
developmental defects, yet the molecular mechanisms explaining its effects on cellular …

An interesting variant of familial glucocorticoid deficiency (FGD), an autosomal recessive
form of adrenal failure, exists in a genetically isolated Irish population. In addition to …

Eukaryotic cells license far more origins than are actually used for DNA replication, thereby
generating a large number of dormant origins. Accumulating evidence suggests that such …

Enabling replicative immortality and uncontrolled cell cycle are hallmarks of cancer cells.
Minichromosome maintenance proteins (MCMs) exhibit helicase activity in replication …

Replicative stress during embryonic development influences ageing and predisposition to
disease in adults. A protective mechanism against replicative stress is provided by the …

Aneuploidy, an aberrant number of chromosomes, has been recognized as a feature of
human malignancies for over a century, but compelling evidence for causality was largely …

The minichromosome maintenance protein homologs MCM8 and MCM9 have previously
been implicated in DNA replication elongation and prereplication complex (pre-RC) …

Human natural killer cell deficiency (NKD) arises from inborn errors of immunity that lead to
impaired NK cell development, function, or both. Through the understanding of the biological …