While meant for wound healing and immunity in response to injury and infection,
inflammatory signaling is usurped by cancerous tumors to promote disease progression …

We report a new mechanism of androgen receptor (AR) mRNA regulation and cytoprotection
in response to AR pathway inhibition (ARPI) stress in prostate cancer (PCA). AR mRNA …

Simple Summary Prostate cancer is the most frequently diagnosed non-cutaneous tumor in
men in the Western world. Therapy for non-organ confined prostate cancer includes anti …

Several types of K+ channels play crucial roles in tumorigenicity, stemness, invasiveness,
and drug resistance in cancer. Spheroid formation of human prostate cancer (PC) LNCaP …

Introduction Inflammation plays a significant role in various cancers, including lung cancer,
where the inflammatory cytokine IL-1β is often elevated in the tumor microenvironment …

The transporter protein lipocalin-2 (LCN2) also termed neutrophil-gelatinase-associated
lipocalin (NGAL) has pleiotropic effects in tumorigenesis in various cancers. Since the …

Reproductive cancers are malignancies that develop in the reproductive organs. One of the
leading cancers affecting the male reproductive system on a global scale is prostate cancer …

The prostate is vulnerable to two major age-associated diseases, cancer and benign
enlargement, which account for significant morbidity and mortality for men across the globe …

Methods: We chronically exposed MDA-PCa-2b cells to IL-1α or IL-1β for several months to
establish sublines. Once established, we determined subline sensitivity to exogenous IL-1 …

Prostate cancer (PCa) is the second most common cause of cancer-related deaths among
American men. Androgen Receptor (AR) transcriptional activity is required for PCa tumor …