Neuro-orchestration of sleep and wakefulness
Although considered an inactive state for centuries, sleep entails many active processes
occurring at the cellular, circuit and organismal levels. Over the last decade, several key …
occurring at the cellular, circuit and organismal levels. Over the last decade, several key …
Functional neuroanatomy of the central noradrenergic system
E Szabadi - Journal of psychopharmacology, 2013 - journals.sagepub.com
The central noradrenergic neurone, like the peripheral sympathetic neurone, is
characterized by a diffusely arborizing terminal axonal network. The central neurones …
characterized by a diffusely arborizing terminal axonal network. The central neurones …
Control of REM sleep by ventral medulla GABAergic neurons
Rapid eye movement (REM) sleep is a distinct brain state characterized by activated
electroencephalogram and complete skeletal muscle paralysis, and is associated with vivid …
electroencephalogram and complete skeletal muscle paralysis, and is associated with vivid …
Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part I: principles of functional organisation
ER Samuels, E Szabadi - Current neuropharmacology, 2008 - ingentaconnect.com
The locus coeruleus (LC) is the major noradrenergic nucleus of the brain, giving rise to
fibres innervating extensive areas throughout the neuraxis. Recent advances in …
fibres innervating extensive areas throughout the neuraxis. Recent advances in …
When the locus coeruleus speaks up in sleep: recent insights, emerging perspectives
A Osorio-Forero, N Cherrad, L Banterle… - International journal of …, 2022 - mdpi.com
For decades, numerous seminal studies have built our understanding of the locus coeruleus
(LC), the vertebrate brain's principal noradrenergic system. Containing a numerically small …
(LC), the vertebrate brain's principal noradrenergic system. Containing a numerically small …
GABA mechanisms and sleep
C Gottesmann - Neuroscience, 2002 - Elsevier
GABA is the main inhibitory neurotransmitter of the CNS. It is well established that activation
of GABAA receptors favors sleep. Three generations of hypnotics are based on these …
of GABAA receptors favors sleep. Three generations of hypnotics are based on these …
The neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorder
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized
by the loss of muscle atonia during paradoxical (REM) sleep (PS). Conversely, cataplexy …
by the loss of muscle atonia during paradoxical (REM) sleep (PS). Conversely, cataplexy …
REM sleep at its core–circuits, neurotransmitters, and pathophysiology
JJ Fraigne, ZA Torontali, MB Snow… - Frontiers in neurology, 2015 - frontiersin.org
Rapid eye movement (REM) sleep is generated and maintained by the interaction of a
variety of neurotransmitter systems in the brainstem, forebrain, and hypothalamus. Within …
variety of neurotransmitter systems in the brainstem, forebrain, and hypothalamus. Within …
Role and origin of the GABAergic innervation of dorsal raphe serotonergic neurons
D Gervasoni, C Peyron, C Rampon… - Journal of …, 2000 - Soc Neuroscience
Extracellular electrophysiological recordings in freely moving cats have shown that
serotonergic neurons from the dorsal raphe nucleus (DRN) fire tonically during wakefulness …
serotonergic neurons from the dorsal raphe nucleus (DRN) fire tonically during wakefulness …
Paradoxical (REM) sleep genesis: the switch from an aminergic–cholinergic to a GABAergic–glutamatergic hypothesis
In the middle of the last century, Michel Jouvet discovered paradoxical sleep (PS), a sleep
phase paradoxically characterized by cortical activation and rapid eye movements and a …
phase paradoxically characterized by cortical activation and rapid eye movements and a …