Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance
LS Waters, BK Minesinger, ME Wiltrout… - Microbiology and …, 2009 - Am Soc Microbiol
SUMMARY DNA repair and DNA damage tolerance machineries are crucial to overcome
the vast array of DNA damage that a cell encounters during its lifetime. In this review, we …
the vast array of DNA damage that a cell encounters during its lifetime. In this review, we …
Translesion synthesis: insights into the selection and switching of DNA polymerases
L Zhao, MT Washington - Genes, 2017 - mdpi.com
DNA replication is constantly challenged by DNA lesions, noncanonical DNA structures and
difficult-to-replicate DNA sequences. Two major strategies to rescue a stalled replication fork …
difficult-to-replicate DNA sequences. Two major strategies to rescue a stalled replication fork …
Roles of DNA polymerases in replication, repair, and recombination in eukaryotes
YI Pavlov, PV Shcherbakova, IB Rogozin - International review of cytology, 2006 - Elsevier
The functioning of the eukaryotic genome depends on efficient and accurate DNA replication
and repair. The process of replication is complicated by the ongoing decomposition of DNA …
and repair. The process of replication is complicated by the ongoing decomposition of DNA …
Participation of DNA Polymerase ζ in Replication of Undamaged DNA in Saccharomyces cerevisiae
MR Northam, HA Robinson, OV Kochenova… - Genetics, 2010 - academic.oup.com
Translesion synthesis DNA polymerases contribute to DNA damage tolerance by mediating
replication of damaged templates. Due to the low fidelity of these enzymes, lesion bypass is …
replication of damaged templates. Due to the low fidelity of these enzymes, lesion bypass is …
Translesion synthesis in mammalian cells
AR Lehmann - Experimental cell research, 2006 - Elsevier
DNA damage blocks the progression of the replication fork. In order to circumvent the
damaged bases, cells employ specialized low stringency DNA polymerases, which are able …
damaged bases, cells employ specialized low stringency DNA polymerases, which are able …
Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells
LK Lerner, G Francisco, DT Soltys… - Nucleic acids …, 2017 - academic.oup.com
Genome lesions trigger biological responses that help cells manage damaged DNA,
improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses …
improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses …
The accurate bypass of pyrimidine dimers by DNA polymerase eta contributes to ultraviolet-induced mutagenesis
Human xeroderma pigmentosum variant (XP-V) patients are mutated in the POLH gene,
responsible for encoding the translesion synthesis (TLS) DNA polymerase eta (Pol eta) …
responsible for encoding the translesion synthesis (TLS) DNA polymerase eta (Pol eta) …
Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability
Translesion synthesis polymerases (TLS Pols) are required to tolerate DNA lesions that
would otherwise cause replication arrest and cell death. Aberrant expression of these …
would otherwise cause replication arrest and cell death. Aberrant expression of these …
High-resolution characterization of CPD hotspot formation in human fibroblasts
Repair of DNA lesions must occur within the chromatin landscape and is associated with
alterations in histone modifications and nucleosome rearrangement. To directly associate …
alterations in histone modifications and nucleosome rearrangement. To directly associate …